TY - JOUR
T1 - Fabrication of aligned PCL scaffold and its guidance for cell growth
AU - Li, Hong
AU - Guo, Zhenzhao
AU - Li, Xiaowei
AU - Liu, Xiaoyan
AU - Wen, Xuejun
AU - Xue, Bo
PY - 2012/10
Y1 - 2012/10
N2 - Aligned and random poly(ε-caprolactone)(PCL) fibrous scaffolds were fabricated via the eletrospinning technique. The morphology, crystallization and mechanical properties of the electrospun scaffolds were characterized by scanning electron microscopy (SEM), wide angle X-ray diffraction(WAXD) and an universal machine test. Osteoblasts were seeded on electrospun scaffolds and the cell growth was evaluated by laser scanning confocal microscope (LSCM) and SEM. The results indicate that the electrospun fibers are smooth and uniform, and about 86.14% fibers are aligned along the selected direction. The tensile strength of the aligned fibers is (27.63±0.75) MPa, which is 232% stronger than that of the random fibers. The elastic modulus does not change significantly, and the elongation at break decreases significantly. The aligned fibers could provide a better guidance towards the cell growth.
AB - Aligned and random poly(ε-caprolactone)(PCL) fibrous scaffolds were fabricated via the eletrospinning technique. The morphology, crystallization and mechanical properties of the electrospun scaffolds were characterized by scanning electron microscopy (SEM), wide angle X-ray diffraction(WAXD) and an universal machine test. Osteoblasts were seeded on electrospun scaffolds and the cell growth was evaluated by laser scanning confocal microscope (LSCM) and SEM. The results indicate that the electrospun fibers are smooth and uniform, and about 86.14% fibers are aligned along the selected direction. The tensile strength of the aligned fibers is (27.63±0.75) MPa, which is 232% stronger than that of the random fibers. The elastic modulus does not change significantly, and the elongation at break decreases significantly. The aligned fibers could provide a better guidance towards the cell growth.
KW - Aligned fibrous scaffold
KW - Cell
KW - Electrospining
KW - Poly(ε-caprolactone)
UR - http://www.scopus.com/inward/record.url?scp=84870287313&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84870287313
SN - 1000-7555
VL - 28
SP - 166
EP - 169
JO - Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering
JF - Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering
IS - 10
ER -