TY - JOUR
T1 - F2-isoprostanes as markers of oxidative stress in vivo
T2 - an overview.
AU - Milne, Ginger L.
AU - Musiek, Erik S.
AU - Morrow, Jason D.
PY - 2005/11
Y1 - 2005/11
N2 - The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a non-enzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes selected aspects regarding current knowledge of these compounds and their value as markers of oxidative injury. Novel aspects related to the biochemistry of isoprostane formation are discussed and methods by which these compounds can be analysed and quantified are summarized. A considerable portion of this article examines the utility of F(2)-isoprostanes as markers of oxidant injury in vivo. Numerous studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation and have illuminated the role of oxidant injury in a number of human diseases including atherosclerosis, Alzheimer's disease and pulmonary disorders.
AB - The isoprostanes are a unique series of prostaglandin-like compounds formed in vivo via a non-enzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes selected aspects regarding current knowledge of these compounds and their value as markers of oxidative injury. Novel aspects related to the biochemistry of isoprostane formation are discussed and methods by which these compounds can be analysed and quantified are summarized. A considerable portion of this article examines the utility of F(2)-isoprostanes as markers of oxidant injury in vivo. Numerous studies carried out over the past decade have shown that these compounds are extremely accurate measures of lipid peroxidation and have illuminated the role of oxidant injury in a number of human diseases including atherosclerosis, Alzheimer's disease and pulmonary disorders.
UR - http://www.scopus.com/inward/record.url?scp=33645569222&partnerID=8YFLogxK
U2 - 10.1080/13547500500216546
DO - 10.1080/13547500500216546
M3 - Review article
C2 - 16298907
AN - SCOPUS:33645569222
SN - 1354-750X
VL - 10 Suppl 1
SP - 10
EP - 23
JO - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ER -