Extreme warfarin sensitivity in siblings associated with multiple cytochrome P450 polymorphisms

Arash Rafii Tabrizi, Sean D. McGrath, Morey A. Blinder, Timothy G. Buchman, Barbara A. Zehnbauer, Bradley D. Freeman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Warfarin use is complicated by an erratic dose response. Warfarin is metabolized by two distinct subfamilies of the cytochrome P450 (CYP) complex. We describe two siblings with extreme sensitivity to warfarin who share an unusual CYP genotype. These individuals illustrate both the importance of genetics in influencing the metabolism of warfarin as well as the potential utility of genetic testing as a guide to prescribing this medication.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalAmerican journal of hematology
Volume67
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Cytochrome P450 complex
  • Siblings
  • Warfarin

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