Extrarenal production of calcitriol

A. Dusso; J. Finch; J. Delmez; N. Rapp; S. Lopez-Hilker; A. Brown; E. Slatopolsky

Extrarenal production of calcitriol

A. Dusso, J. Finch, J. Delmez, N. Rapp, S. Lopez-Hilker, A. Brown, E. Slatopolsky

Division of Endocrinology, Metabolism & Lipid Research

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. Under pathological conditions such as chronic renal failure, extrarenal sources have the potential to normalize serum calcitriol after adequate stimulation (such as, 25(OH)D administration). Extrarenal 1,25(OH)₂D₃ synthesis is controlled by physiological levels of calcitriol. However, in sarcoidosis and other granulomatous diseases, 1,25-(OH)₂D₃ production by macrophages is deregulated, causing severe alterations in systemic calcium homeostasis.

Original language	English
Pages (from-to)	S-36-S-40
Journal	Kidney International
Volume	38
Issue number	SUPPL. 29
State	Published - 1990

Cite this

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title = "Extrarenal production of calcitriol",

abstract = "Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. Under pathological conditions such as chronic renal failure, extrarenal sources have the potential to normalize serum calcitriol after adequate stimulation (such as, 25(OH)D administration). Extrarenal 1,25(OH)2D3 synthesis is controlled by physiological levels of calcitriol. However, in sarcoidosis and other granulomatous diseases, 1,25-(OH)2D3 production by macrophages is deregulated, causing severe alterations in systemic calcium homeostasis.",

author = "A. Dusso and J. Finch and J. Delmez and N. Rapp and S. Lopez-Hilker and A. Brown and E. Slatopolsky",

year = "1990",

language = "English",

volume = "38",

pages = "S--36--S--40",

journal = "Kidney International",

issn = "0085-2538",

number = "SUPPL. 29",

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TY - JOUR

T1 - Extrarenal production of calcitriol

AU - Dusso, A.

AU - Finch, J.

AU - Delmez, J.

AU - Rapp, N.

AU - Lopez-Hilker, S.

AU - Brown, A.

AU - Slatopolsky, E.

PY - 1990

Y1 - 1990

N2 - Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. Under pathological conditions such as chronic renal failure, extrarenal sources have the potential to normalize serum calcitriol after adequate stimulation (such as, 25(OH)D administration). Extrarenal 1,25(OH)2D3 synthesis is controlled by physiological levels of calcitriol. However, in sarcoidosis and other granulomatous diseases, 1,25-(OH)2D3 production by macrophages is deregulated, causing severe alterations in systemic calcium homeostasis.

AB - Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. Under pathological conditions such as chronic renal failure, extrarenal sources have the potential to normalize serum calcitriol after adequate stimulation (such as, 25(OH)D administration). Extrarenal 1,25(OH)2D3 synthesis is controlled by physiological levels of calcitriol. However, in sarcoidosis and other granulomatous diseases, 1,25-(OH)2D3 production by macrophages is deregulated, causing severe alterations in systemic calcium homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=0025118432&partnerID=8YFLogxK

M3 - Review article

C2 - 2214546

AN - SCOPUS:0025118432

SN - 0085-2538

VL - 38

SP - S-36-S-40

JO - Kidney International

JF - Kidney International

IS - SUPPL. 29

ER -

Extrarenal production of calcitriol

Abstract

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