TY - JOUR
T1 - Extrapulmonary pneumocystis carinii infections
AU - Telzak, Edward E.
AU - Cote, Richard J.
AU - Gold, Jonathan W.M.
AU - Campbell, Suzanne W.
AU - Armstrong, Donald
PY - 1990/5
Y1 - 1990/5
N2 - A case of disseminated infection with Pneumocystis carinii is presented, and the English-language literature is reviewed for cases of documented extrapulmonary infection with this organism. In this case - with P. carinii diffusely replacing the bone marrow and causing hepatic, adrenal, and glomerular tuft necrosis - the clinical illness and multiple-organ dysfunction attributed to disseminated P. carinii were more severe than had previously been described. Because the rate of extrapulmonary P. carinii infection found at autopsy in patients with AIDS is at least 2.5% at our institution, we caution against the routine use of aerosol rather than parenteral pentamidine for treatment of P. carinii pneumonia until additional data are available.
AB - A case of disseminated infection with Pneumocystis carinii is presented, and the English-language literature is reviewed for cases of documented extrapulmonary infection with this organism. In this case - with P. carinii diffusely replacing the bone marrow and causing hepatic, adrenal, and glomerular tuft necrosis - the clinical illness and multiple-organ dysfunction attributed to disseminated P. carinii were more severe than had previously been described. Because the rate of extrapulmonary P. carinii infection found at autopsy in patients with AIDS is at least 2.5% at our institution, we caution against the routine use of aerosol rather than parenteral pentamidine for treatment of P. carinii pneumonia until additional data are available.
UR - http://www.scopus.com/inward/record.url?scp=0025326429&partnerID=8YFLogxK
U2 - 10.1093/clinids/12.3.380
DO - 10.1093/clinids/12.3.380
M3 - Article
C2 - 2193343
AN - SCOPUS:0025326429
SN - 1058-4838
VL - 12
SP - 380
EP - 386
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 3
ER -