Extrapineal N-acetyltransferase activity in rat brain

Steven M. Paul, Louise L. Hsu, Arnold J. Mandell

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


An extrapineal enzyme that N-acetylates a variety of indole and catechol alkylamines, including the psychoactive drugs mescaline and d-amphetamine, has been partially purified from rat brain. This enzymatic activity has a distinct pH optimum, is linear with incubation time and protein concetration, and is abolished by heating. Purification is approximately ten fold with ammonium sulfate precipitation and column chromatography, yielding a specific activity of 7936 pmoles of product per mg of protein per hour with tryptamine as substrate.

Original languageEnglish
Pages (from-to)2135-2143
Number of pages9
JournalLife Sciences
Issue number12
StatePublished - Dec 15 1974


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