Extramammary Paget's disease of the scrotum with complete response to imiquimod and photodynamic therapy

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm with an extremely variable clinical course. The objective of this study was to determine if combination imiquimod and photodynamic therapy could induce remission of EMPD. A 69-year-old man with EMPD was treated with topical imiquimod 5% cream at night for 5 days per week for 1 month, followed by 2 months of 5% imiquimod for three nights a week. For the following 6 months, monthly 5-aminolevulinic acid photodynamic therapy was added. After 6 months, imiquimod was discontinued and the patient continued to be treated with quarterly photodynamic therapy. Treatment resulted in significant improvement in the appearance of the lesion, and pathology revealed no evidence of residual disease. The patient has had no clinical signs of disease for >5 years. We conclude that topical imiquimod 5% cream and photodynamic therapy may aid in the treatment of some patients with EMPD.

Original languageEnglish
Article number221696
JournalBMJ Case Reports
Volume2018
DOIs
StatePublished - Jan 1 2018

Keywords

  • dermatology
  • immunology
  • prostate cancer

Fingerprint Dive into the research topics of 'Extramammary Paget's disease of the scrotum with complete response to imiquimod and photodynamic therapy'. Together they form a unique fingerprint.

  • Cite this