TY - JOUR
T1 - Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia
AU - on behalf of the Children’s Hospitals Neonatal Consortium’s (CHNC) Congenital Diaphragmatic Hernia Focus Group
AU - Keene, Sarah
AU - Grover, Theresa R.
AU - Murthy, Karna
AU - Pallotto, Eugenia K.
AU - Brozanski, Beverly
AU - Gien, Jason
AU - Zaniletti, Isabella
AU - Johnson, Yvette R.
AU - Seabrook, Ruth B.
AU - Porta, Nicolas F.M.
AU - Haberman, Beth
AU - DiGeronimo, Robert
AU - Rintoul, Natalie
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Objective: To characterize the risk of bloodstream (BSI) and urinary tract infection (UTI) and describe antibiotic use in infants with congenital diaphragmatic hernia (CDH) requiring extracorporeal membrane oxygenation (ECMO). Study design: The Children’s Hospitals Neonatal Database was queried for infants with CDH and ECMO treatment from 2010 to 2016. The outcomes included BSI, UTI, and antimicrobial medication. Member institutions completed a survey on infection practices. Result: Eighteen of the 338 patients identified (5.3%) had ≥1 BSI during their ECMO course. The likelihood of BSI increased with time: 1.2/1000 ECMO days; 0.6% (2/315) in the first week and rising to 14.6/1000; 8.6% (5/58) after 21 days (p = 0.002). More than 95% of patients received antibiotics each week on ECMO. Conclusions: Confirmed BSI is rare in infants with CDH treated with ECMO in the first week, but increases with the duration of ECMO. Use of antibiotics was extensive and did not correspond to infection frequency.
AB - Objective: To characterize the risk of bloodstream (BSI) and urinary tract infection (UTI) and describe antibiotic use in infants with congenital diaphragmatic hernia (CDH) requiring extracorporeal membrane oxygenation (ECMO). Study design: The Children’s Hospitals Neonatal Database was queried for infants with CDH and ECMO treatment from 2010 to 2016. The outcomes included BSI, UTI, and antimicrobial medication. Member institutions completed a survey on infection practices. Result: Eighteen of the 338 patients identified (5.3%) had ≥1 BSI during their ECMO course. The likelihood of BSI increased with time: 1.2/1000 ECMO days; 0.6% (2/315) in the first week and rising to 14.6/1000; 8.6% (5/58) after 21 days (p = 0.002). More than 95% of patients received antibiotics each week on ECMO. Conclusions: Confirmed BSI is rare in infants with CDH treated with ECMO in the first week, but increases with the duration of ECMO. Use of antibiotics was extensive and did not correspond to infection frequency.
UR - http://www.scopus.com/inward/record.url?scp=85070248371&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0435-5
DO - 10.1038/s41372-019-0435-5
M3 - Article
C2 - 31383944
AN - SCOPUS:85070248371
SN - 0743-8346
VL - 39
SP - 1384
EP - 1391
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 10
ER -