Extracellular redox modulation by regulatory T cells

Zhonghua Yan; Sanjay K. Garg; Jonathan Kipnis; Ruma Banerjee

doi:10.1038/nchembio.212

Extracellular redox modulation by regulatory T cells

Zhonghua Yan
, Sanjay K. Garg
, Jonathan Kipnis
, Ruma Banerjee

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.

Original language	English
Pages (from-to)	721-723
Number of pages	3
Journal	Nature Chemical Biology
Volume	5
Issue number	10
DOIs	https://doi.org/10.1038/nchembio.212
State	Published - Oct 2009

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10.1038/nchembio.212

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title = "Extracellular redox modulation by regulatory T cells",

abstract = "We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.",

author = "Zhonghua Yan and Garg, \{Sanjay K.\} and Jonathan Kipnis and Ruma Banerjee",

note = "Funding Information: This work was supported in part by a grant from the US National Institutes of Health (DK64959 and NIH5P60 DK20572).",

year = "2009",

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AU - Yan, Zhonghua

AU - Garg, Sanjay K.

AU - Kipnis, Jonathan

AU - Banerjee, Ruma

N1 - Funding Information: This work was supported in part by a grant from the US National Institutes of Health (DK64959 and NIH5P60 DK20572).

PY - 2009/10

Y1 - 2009/10

N2 - We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.

AB - We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.

UR - https://www.scopus.com/pages/publications/70349314830

U2 - 10.1038/nchembio.212

DO - 10.1038/nchembio.212

M3 - Article

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AN - SCOPUS:70349314830

SN - 1552-4450

VL - 5

SP - 721

EP - 723

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 10

ER -

Extracellular redox modulation by regulatory T cells

Abstract

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