TY - JOUR
T1 - Extracellular redox modulation by regulatory T cells
AU - Yan, Zhonghua
AU - Garg, Sanjay K.
AU - Kipnis, Jonathan
AU - Banerjee, Ruma
N1 - Funding Information:
This work was supported in part by a grant from the US National Institutes of Health (DK64959 and NIH5P60 DK20572).
PY - 2009/10
Y1 - 2009/10
N2 - We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
AB - We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.
UR - http://www.scopus.com/inward/record.url?scp=70349314830&partnerID=8YFLogxK
U2 - 10.1038/nchembio.212
DO - 10.1038/nchembio.212
M3 - Article
C2 - 19718041
AN - SCOPUS:70349314830
SN - 1552-4450
VL - 5
SP - 721
EP - 723
JO - Nature Chemical Biology
JF - Nature Chemical Biology
IS - 10
ER -