Extracellular redox modulation by regulatory T cells

Zhonghua Yan, Sanjay K. Garg, Jonathan Kipnis, Ruma Banerjee

Research output: Contribution to journalArticlepeer-review

111 Scopus citations

Abstract

We demonstrate that the mechanism of redox remodeling during mouse T-cell activation involves secretion of glutathione by dendritic cells and its subsequent cleavage to cysteine. Extracellular cysteine accumulation results in a lower redox potential, which is conducive to proliferation, and changes the net redox status of exofacial protein domains. Regulatory T cells inhibit this redox metabolite signaling pathway, which represents a previously unrecognized mechanism for immunosuppression of effector T cells.

Original languageEnglish
Pages (from-to)721-723
Number of pages3
JournalNature Chemical Biology
Volume5
Issue number10
DOIs
StatePublished - Oct 2009

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