Extracellular matrix regulation in the muscle satellite cell niche

Kelsey Thomas, Adam J. Engler, Gretchen A. Meyer

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations

Abstract

Increasing evidence points to extracellular matrix (ECM) components playing integral roles in regulating the muscle satellite cell (SC) niche. Even small alterations to the niche ECM can have profound effects on SC localization, activation, self-renewal, proliferation and differentiation. This review will focus on the ECM components that comprise the niche, how they are modulated in health and disease and how these changes are thought to affect SC function. Particular emphasis will be placed on the pathological niche and interventions that aim to restore healthy structure and function, as a better understanding of the interplay between the SC and its environment will drive more targeted and effective therapies.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalConnective Tissue Research
Volume56
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • Basement membrane
  • Collagen
  • Proteoglycan
  • Satellite cell
  • Stem cell

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