TY - JOUR
T1 - Extinction-induced mirror responding as a baseline for studying drug effects on aggression
AU - Moore, Mitchell S.
AU - Lawrence Tychsen, R.
AU - Thompson, Donald M.
N1 - Funding Information:
Two adult male White Carneaux pigeons were used. Both had been used previously in drug experiments involving extinction-induced mirror responding [15]. The pigeons were maintained within l0 g of 80 percent of their free-feeding weights throughout the research by food presented during the sessions and by postsession supplemental feeding. The 80 percent values were 552 g and 524 g for 1 This research was supported by Public Health Service Grants FR 5360 and FR 5306. The chlordiazepoxide (Librium) was kindly donated by Hoffmann-LaRoche Inc. We wish to thank Dr. Annette S. Thompson for comments on the manuscript.
PY - 1976/1
Y1 - 1976/1
N2 - Pigeons worked individually in a chamber containing a response key and a mirror. Responding on the key was controlled by a multiple schedule in which a brief period of continuous food reinforcement alternated with a 5 min period of extinction. Under baseline conditions, aggressive behavior (responding on the mirror) occured at the onset of each extinction period. After 10 saline control sessions, 5 mg/kg of chlordiazepoxide was injected IM 30 min pressesion for 60 daily sessions. The drug initially produced a marked decrease in aggressive behavior but had little or no effect on key pecking. The aggressive behavior generally remained suppressed during the chronic drug regimen and returned to control levels when the drug was withdrawn. It was concluded that the technique of extinction-induced mirror responding in pigeons provides a stable, sensitive and recoverable baseline for objectively assessing selective drug effects on aggression.
AB - Pigeons worked individually in a chamber containing a response key and a mirror. Responding on the key was controlled by a multiple schedule in which a brief period of continuous food reinforcement alternated with a 5 min period of extinction. Under baseline conditions, aggressive behavior (responding on the mirror) occured at the onset of each extinction period. After 10 saline control sessions, 5 mg/kg of chlordiazepoxide was injected IM 30 min pressesion for 60 daily sessions. The drug initially produced a marked decrease in aggressive behavior but had little or no effect on key pecking. The aggressive behavior generally remained suppressed during the chronic drug regimen and returned to control levels when the drug was withdrawn. It was concluded that the technique of extinction-induced mirror responding in pigeons provides a stable, sensitive and recoverable baseline for objectively assessing selective drug effects on aggression.
KW - Chronic chlordiazepoxide administration
KW - Extinction-induced aggression
KW - Mirror responding
UR - http://www.scopus.com/inward/record.url?scp=0017293739&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(76)90181-7
DO - 10.1016/0091-3057(76)90181-7
M3 - Article
C2 - 944450
AN - SCOPUS:0017293739
SN - 0091-3057
VL - 4
SP - 99
EP - 102
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 1
ER -