External beam radiation therapy for PTFE dialysis grafts: A pilot study

Prabir Roy-Chaudhury; Heather J. Duncan; Darryl Zuckerman; Rashid Faiyaz; Rino Munda; Shashi Kant; Burnett Kelly; Ashwatha Narayana

doi:10.5301/jva.5000052

External beam radiation therapy for PTFE dialysis grafts: A pilot study

Prabir Roy-Chaudhury, Heather J. Duncan, Darryl Zuckerman, Rashid Faiyaz, Rino Munda, Shashi Kant, Burnett Kelly, Ashwatha Narayana

Department of Radiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.

Original language	English
Pages (from-to)	329-331
Number of pages	3
Journal	Journal of Vascular Access
Volume	13
Issue number	3
DOIs	https://doi.org/10.5301/jva.5000052
State	Published - Jul 2012

Keywords

External beam radiation
Neointimal hyperplasia
PTFE dialysis graft
Stenosis

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title = "External beam radiation therapy for PTFE dialysis grafts: A pilot study",

abstract = "Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.",

keywords = "External beam radiation, Neointimal hyperplasia, PTFE dialysis graft, Stenosis",

author = "Prabir Roy-Chaudhury and Duncan, {Heather J.} and Darryl Zuckerman and Rashid Faiyaz and Rino Munda and Shashi Kant and Burnett Kelly and Ashwatha Narayana",

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T1 - External beam radiation therapy for PTFE dialysis grafts

T2 - A pilot study

AU - Roy-Chaudhury, Prabir

AU - Duncan, Heather J.

AU - Zuckerman, Darryl

AU - Faiyaz, Rashid

AU - Munda, Rino

AU - Kant, Shashi

AU - Kelly, Burnett

AU - Narayana, Ashwatha

PY - 2012/7

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N2 - Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.

AB - Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.

KW - External beam radiation

KW - Neointimal hyperplasia

KW - PTFE dialysis graft

KW - Stenosis

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External beam radiation therapy for PTFE dialysis grafts: A pilot study

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