External beam radiation therapy for PTFE dialysis grafts: A pilot study

Prabir Roy-Chaudhury, Heather J. Duncan, Darryl Zuckerman, Rashid Faiyaz, Rino Munda, Shashi Kant, Burnett Kelly, Ashwatha Narayana

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.

Original languageEnglish
Pages (from-to)329-331
Number of pages3
JournalJournal of Vascular Access
Volume13
Issue number3
DOIs
StatePublished - Jul 2012

Keywords

  • External beam radiation
  • Neointimal hyperplasia
  • PTFE dialysis graft
  • Stenosis

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