External beam radiation therapy for PTFE dialysis grafts: A pilot study

Prabir Roy-Chaudhury; Heather J. Duncan; Darryl Zuckerman; Rashid Faiyaz; Rino Munda; Shashi Kant; Burnett Kelly; Ashwatha Narayana

doi:10.5301/jva.5000052

External beam radiation therapy for PTFE dialysis grafts: A pilot study

Prabir Roy-Chaudhury, Heather J. Duncan, Darryl Zuckerman, Rashid Faiyaz, Rino Munda, Shashi Kant, Burnett Kelly, Ashwatha Narayana

Radiology

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.

Original language	English
Pages (from-to)	329-331
Number of pages	3
Journal	Journal of Vascular Access
Volume	13
Issue number	3
DOIs	https://doi.org/10.5301/jva.5000052
State	Published - Jul 1 2012

Keywords

External beam radiation
Neointimal hyperplasia
PTFE dialysis graft
Stenosis

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Roy-Chaudhury, P., Duncan, H. J., Zuckerman, D., Faiyaz, R., Munda, R., Kant, S., Kelly, B., & Narayana, A. (2012). External beam radiation therapy for PTFE dialysis grafts: A pilot study. Journal of Vascular Access, 13(3), 329-331. https://doi.org/10.5301/jva.5000052

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abstract = "Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.",

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AU - Faiyaz, Rashid

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AU - Kant, Shashi

AU - Kelly, Burnett

AU - Narayana, Ashwatha

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AB - Purpose: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction. Methods: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention. Results: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention. Conclusions: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.

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