TY - GEN
T1 - Extending the image resolution of animal pet via accessory insert devices
AU - Tai, Yuan Chuan
AU - Wu, Heyu
AU - Pal, Debashish
AU - O'Sullivan, Joseph A.
PY - 2008/9/10
Y1 - 2008/9/10
N2 - We have developed two prototype micro insert devices based on a novel virtual-pinhole PET geometry. These devices can be integrated into an animal PET scanner to significantly enhance its image resolution. The first system consists of a rotation stage that rotates a high-resolution detector module within the animal port. The second system consists of 18 detector modules arranged in a ring. While both systems are capable of higher resolution PET imaging, the second approach enables dynamic and gated imaging, as well as higher sensitivity. Image reconstruction algorithms that specifically model the virtual-pinhole PET geometry are developed for the PET insert systems. Preliminary imaging experiments show improvement in transverse image resolution. To achieve quantitative accuracy, refined correction techniques for attenuation and scatter, as well as system normalization and detector dead time, will need to be developed for PET insert devices.
AB - We have developed two prototype micro insert devices based on a novel virtual-pinhole PET geometry. These devices can be integrated into an animal PET scanner to significantly enhance its image resolution. The first system consists of a rotation stage that rotates a high-resolution detector module within the animal port. The second system consists of 18 detector modules arranged in a ring. While both systems are capable of higher resolution PET imaging, the second approach enables dynamic and gated imaging, as well as higher sensitivity. Image reconstruction algorithms that specifically model the virtual-pinhole PET geometry are developed for the PET insert systems. Preliminary imaging experiments show improvement in transverse image resolution. To achieve quantitative accuracy, refined correction techniques for attenuation and scatter, as well as system normalization and detector dead time, will need to be developed for PET insert devices.
KW - Animal PET
KW - High resolution imaging
KW - PET insert
KW - Virtual-pinhole PET
UR - http://www.scopus.com/inward/record.url?scp=51049117905&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2008.4541271
DO - 10.1109/ISBI.2008.4541271
M3 - Conference contribution
AN - SCOPUS:51049117905
SN - 9781424420032
T3 - 2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, Proceedings, ISBI
SP - 1413
EP - 1416
BT - 2008 5th IEEE International Symposium on Biomedical Imaging
Y2 - 14 May 2008 through 17 May 2008
ER -