@article{935617b7a7f743a683a920d15651df6e,
title = "Extending the Environmental influences on Child Health Outcomes (ECHO) Cohort through 2030: Rationale and study protocol",
abstract = "Early life environmental exposures, even those experienced before conception, can shape health and disease trajectories across the lifespan. Optimizing the detection of the constellation of exposure effects on a broad range of child health outcomes across development requires considerable sample size, transdisciplinary expertise, and developmentally sensitive and dimensional measurement. To address this, the National Institutes of Health (NIH) Environmental influences on Child Health Outcomes (ECHO) Cohort Study is an observational longitudinal pediatric cohort study. In the first phase from 2016–2023, the ECHO Program built a robust platform for investigating prenatal and early life environmental exposures on child health outcomes. Now, the ECHO Program is extending longitudinal follow-up of existing ECHO participants <21 years of age and recruiting and following new pregnant participants <20 weeks gestation and their offspring through 2030. Participants will be enrolled at 72 Cohort Study Sites across all 50 US states, the District of Columbia, and Puerto Rico. Exposure assessments span the biological, chemical/physical, lifestyle, and social environment; child health outcomes focus on five broad domains: pre-, peri-, postnatal; airways; obesity; neurodevelopment; and positive health, or one{\textquoteright}s physical, mental, and social well-being. Data and biospecimens will be collected annually through August 2030, with an expected total sample size of 60,000 children and their caregivers. The ECHO Cohort Study represents the largest national longitudinal study of children{\textquoteright}s health in the US. Here, we describe the ECHO Cohort “Cycle 2” observational study arm and the ECHO Cohort Protocol version 3.0 (ECP v3.0), which delineates the data elements, measures, and biospecimens that all ECHO Cycle 2 Cohort Study Sites will collect and analyze.",
author = "{ECHO Cohort Consortium} and Blackwell, {Courtney K.} and David Cella and Linda Adair and Cordero, {Jos{\'e} F.} and Das, {Suman R.} and Elliott, {Amy J.} and Hipwell, {Alison E.} and Jacobson, {Lisa P.} and Neiderhiser, {Jenae M.} and Stanford, {Joseph B.} and Wright, {Rosalind J.} and Richard Gershon and Gillman, {M. W.} and S. Arteaga and Smith, {P. B.} and Newby, {L. K.} and L. Adair and Jacobson, {L. P.} and Catellier, {D. J.} and R. Gershon and D. Cella and Das, {S. R.} and Freedman, {J. E.} and Mallal, {S. I.} and McLean, {J. A.} and R. Shah and Whitworth, {K. W.} and Northrup, {T. F.} and E. Symanski and Herbstman, {J. B.} and A. Margolis and Miller, {R. L.} and M. Karagas and J. Mandan and K. Lyall and A. Dunlop and Brennan, {P. A.} and A. Stroustrup and B. Rochelson and Aschner, {J. L.} and Ganiban, {J. M.} and E. Oken and Hacker, {M. R.} and James-Todd, {T. M.} and Kerver, {J. M.} and Barone, {C. J.} and Elliott, {M. R.} and C. Fussman and Paneth, {N. S.} and Ruden, {D. M.} and Wright, {R. J.} and Wright, {R. O.} and Carroll, {K. N.} and H. Volk and A. Ferrara and Croen, {L. A.} and Hedderson, {M. M.} and Avalos, {L. A.} and Y. Zhu and A. Hamvas and Yee, {L. M.} and Camargo, {C. A.} and K. Hunt and Newman, {R. B.} and L. Trasande and Alshawabkeh, {A. N.} and C. McEvoy and Spindel, {E. R.} and Neiderhiser, {J. M.} and J. Slaughter and S. Keim and {Koinis Mitchell}, D. and D{\textquoteright}Sa, {V. A.} and Barrett, {E. S.} and Blaser, {M. J.} and Dominguez-Bello, {M. G.} and Horton, {D. B.} and Jimenez, {M. E.} and K. Palomares and S. Sathyanarayana and Collett, {B. R.} and Venkatesh, {K. K.} and Lynch, {C. D.} and I. Hertz-Picciotto and Bennett, {D. H.} and Schmidt, {R. J.} and Schweitzer, {J. B.} and H. Mueller and LeWinn, {K. Z.} and Bush, {N. R.} and D. Dabalea and Bekelman, {T. A.} and Moore, {B. F.} and W. Perng and A. Starling and Codero, {J. F.} and Schantz, {S. L.} and H. Santos and Paidas, {M. J.} and Nguyen, {H. N.B.} and D. MacKenzie and J. Lewis and O{\textquoteright}Shea, {T. M.} and R. Fry and L. Leve and Mumford, {S. L.} and Burris, {H. H.} and DeMauro, {S. B.} and Hipwell, {A. E.} and O{\textquoteright}Connor, {T. G.} and E. Barrett and Miller, {R. K.} and K. Scheible and Q. Zhao and Stanford, {J. B.} and C. Porucznik and Karr, {C. J.} and Gern, {J. E.} and Singh, {A. M.} and T. Hartert and Osmundson, {S. S.} and Bacharier, {L. B.} and K. Rivera-Spoljaric",
note = "Publisher Copyright: Copyright: {\textcopyright} 2024 Blackwell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2024",
month = dec,
doi = "10.1371/journal.pone.0312677",
language = "English",
volume = "19",
journal = "PloS one",
issn = "1932-6203",
number = "12 December",
}