TY - JOUR
T1 - Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding
AU - Luskin, Andrew T.
AU - Bhatti, Dionnet L.
AU - Mulvey, Bernard
AU - Pedersen, Christian E.
AU - Girven, Kasey S.
AU - Oden-Brunson, Hannah
AU - Kimbell, Kate
AU - Blackburn, Taylor
AU - Sawyer, Abbie
AU - Gereau, Robert W.
AU - Dougherty, Joseph D.
AU - Bruchas, Michael R.
N1 - Publisher Copyright:
Copyright © 2021 The Authors, some rights reserved.
PY - 2021/2/24
Y1 - 2021/2/24
N2 - An animal's evolutionary success depends on the ability to seek and consume foods while avoiding environmental threats. However, how evolutionarily conserved threat detection circuits modulate feeding is unknown. In mammals, feeding and threat assessment are strongly influenced by the parabrachial nucleus (PBN), a structure that responds to threats and inhibits feeding. Here, we report that the PBN receives dense inputs from two discrete neuronal populations in the bed nucleus of the stria terminalis (BNST), an extended amygdala structure that encodes affective information. Using a series of complementary approaches, we identify opposing BNST-PBN circuits that modulate neuropeptide-expressing PBN neurons to control feeding and affective states. These previously unrecognized neural circuits thus serve as potential nodes of neural circuitry critical for the integration of threat information with the intrinsic drive to feed.
AB - An animal's evolutionary success depends on the ability to seek and consume foods while avoiding environmental threats. However, how evolutionarily conserved threat detection circuits modulate feeding is unknown. In mammals, feeding and threat assessment are strongly influenced by the parabrachial nucleus (PBN), a structure that responds to threats and inhibits feeding. Here, we report that the PBN receives dense inputs from two discrete neuronal populations in the bed nucleus of the stria terminalis (BNST), an extended amygdala structure that encodes affective information. Using a series of complementary approaches, we identify opposing BNST-PBN circuits that modulate neuropeptide-expressing PBN neurons to control feeding and affective states. These previously unrecognized neural circuits thus serve as potential nodes of neural circuitry critical for the integration of threat information with the intrinsic drive to feed.
UR - http://www.scopus.com/inward/record.url?scp=85102142766&partnerID=8YFLogxK
U2 - 10.1126/sciadv.abd3666
DO - 10.1126/sciadv.abd3666
M3 - Article
C2 - 33637526
AN - SCOPUS:85102142766
SN - 2375-2548
VL - 7
JO - Science Advances
JF - Science Advances
IS - 9
M1 - eabd3666
ER -