Expression of the Purkinje cell specific zebrin antigens in the cerebellum of the meander tail mutant mouse

The cerebellum of the meander tail mutant mouse is characterized by normal cytoarchitecture in the posterior lobe and agranular, abnormal cytoarchitecture in the anterior lobe. The Purkinje cells form a monolayer in the posterior lobe but are dispersed throughout the cortex of the anterior lobe. Examination of these cells with the zebrin antibodies demonstrates that in spite of the morphologic and laminar disorganization of these cells in the anterior lobe, they are organized into the appropriate number of correctly positioned immunopositive zebrin clusters.