Expression of the neurofibromatosis 1 (NF1) gene during growth arrest

Karen K. Norton, Debbie K. Mahadeo, Robert T. Geist, David H. Gutmann

Research output: Contribution to journalArticle

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Abstract

The neurofibromatosis 1 (NF1) gene product, neurofibromin, is a tumor suppressor gene product capable of inhibiting the growth of cells in culture. If neurofibromin suppresses cell growth by arresting cells in G0 or G1, its expression might be regulated in a cell cycle-dependent fashion. In this study, we demonstrate that RAT-1A fibroblasts arrested in G0/G1 by serum starvation and then released to progress through the cell cycle do not demonstrate significant changes in NF1 expression. However, when arrested in G0/G1 by contact inhibition, NF1 expression in these cells is reversibly upregulated within 72 h, suggesting that NF1 expression is a late event associated with cell growth arrest which may contribute to the maintenance of the differentiated state.

Original languageEnglish
Pages (from-to)601-604
Number of pages4
JournalNeuroReport
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • cell cycle
  • growth arrest
  • neurofibromatosis
  • neurofibromin
  • tumor suppressor gene

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