TY - JOUR
T1 - Expression of Surfactant Protein D Distinguishes Severe Pandemic Influenza A(H1N1) from Coronavirus Disease 2019
AU - Choreño-Parra, José Alberto
AU - Jiménez-Álvarez, Luis Armando
AU - Ramírez-Martínez, Gustavo
AU - Cruz-Lagunas, Alfredo
AU - Thapa, Mahima
AU - Fernández-López, Luis Alejandro
AU - Carnalla-Cortés, Martha
AU - Choreño-Parra, Eduardo M.
AU - Mena-Hernández, Lourdes
AU - Sandoval-Vega, Montserrat
AU - Hernández-Montiel, Erika Mariana
AU - Hernández-García, Diana Lizzeth
AU - Ramírez-Noyola, Jazmín Ariadna
AU - Reyes-López, Cynthia Estefania
AU - Domínguez-Faure, Andrea
AU - Zamudio-López, Guillermo Yamil
AU - Márquez-García, Eduardo
AU - Moncada-Morales, Angélica
AU - Mendoza-Milla, Criselda
AU - Cervántes-Rosete, Diana
AU - Muñoz-Torrico, Marcela
AU - Luna-Rivero, Cesar
AU - García-Latorre, Ethel A.
AU - Guadarrama-Ortíz, Parménides
AU - Ávila-Moreno, Federico
AU - Domínguez-Cherit, Guillermo
AU - Rodríguez-Reyna, Tatiana Sofía
AU - Mudd, Philip A.
AU - Hernández-Cárdenas, Carmen Margarita
AU - Khader, Shabaana A.
AU - Zúñiga, Joaquín
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - The differentiation between influenza and coronavirus disease 2019 (COVID-19) could constitute a diagnostic challenge during the ongoing winter owing to their clinical similitude. Thus, novel biomarkers are required to enable making this distinction. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in patients with severe pandemic influenza but not those with COVID-19. This finding was validated in a separate cohort of mechanically ventilated patients with COVID-19 who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with death and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19.
AB - The differentiation between influenza and coronavirus disease 2019 (COVID-19) could constitute a diagnostic challenge during the ongoing winter owing to their clinical similitude. Thus, novel biomarkers are required to enable making this distinction. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in patients with severe pandemic influenza but not those with COVID-19. This finding was validated in a separate cohort of mechanically ventilated patients with COVID-19 who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with death and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19.
KW - COVID-19
KW - SARS-CoV-2
KW - acute respiratory distress syndrome
KW - influenza A(H1N1)pdm09
KW - surfactant protein D
UR - http://www.scopus.com/inward/record.url?scp=85110060563&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiab113
DO - 10.1093/infdis/jiab113
M3 - Article
C2 - 33668070
AN - SCOPUS:85110060563
SN - 0022-1899
VL - 224
SP - 21
EP - 30
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -