Expression of m157, a murine cytomegalovirus-encoded putative major histocompatibility class I (MHC-I)-like protein, is independent of viral regulation of host MHC-I

Sandeep K. Tripathy, Hamish R.C. Smith, Erika A. Holroyd, Jeanette T. Pingel, Wayne M. Yokoyama

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A murine cytomegalovirus (MCMV)-encoded protein, m157, has a putative major histocompatibility complex class I (MHC-I) structure and is recognized by the Ly49H NK cell activation receptor. Using a monoclonal antibody against m157, in this study we directly demonstrated that m157 is a cell surface-expressed glycophosphatidylinositol-anchored protein with early viral gene kinetics. Beta-2 microglobulin and TAP1 (transporter associated with antigen processing 1) were not required for its expression. MCMV-encoded proteins that down-regulate MHC-I did not affect the expression of m157. Thus, m157 is expressed on infected cells in a manner independent of viral regulation of host MHC-I.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalJournal of virology
Volume80
Issue number1
DOIs
StatePublished - Jan 1 2006

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