Expression of hexokinase II and Glut-1 in untreated human breast cancer

Raya S. Brown, Tonya M. Goodman, Kenneth R. Zasadny, Joel K. Greenson, Richard L. Wahl

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

Expressions of HKII and Glut-1 were studied in untreated primary human breast cancers by immunohistochemistry. 79% of the breast cancers were HKII-positive and 61% were Glut-1-positive. Average positive malignant cell areas were 66 ± 41% for HKII and 29 ± 36% for Glut-1. HKII staining was cytoplasmic, suggesting mitochondrial localization with no variations in staining intensities. Glut-1 staining was heterogeneous, cytoplasmic and membranous and varied with histology and tumor stage. Cells expressing HKII did not always express Glut-1 and vice versa. Increased FDG-uptake appeared to be associated with increased Glut-1 expression (P = 0.021), but not with HKII expression (p = 0.6). FDG uptake in breast cancer tissue appears to be associated with the extent of immunodetectable expression of Glut-1, but not that of HKII, and FDG uptake may differ between individual tumors depending on tumor stage and histology.

Original languageEnglish
Pages (from-to)443-453
Number of pages11
JournalNuclear Medicine and Biology
Volume29
Issue number4
DOIs
StatePublished - Jun 17 2002
Externally publishedYes

Keywords

  • F-FDG-PET
  • Glucose metabolism
  • Glut-1
  • Hexokinase II
  • Human breast cancer
  • Immunohistochemistry

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