TY - JOUR
T1 - Expression of fibronectin and its cell surface receptors
AU - Dean, D. C.
AU - Birkenmeier, T. M.
AU - Rosen, G. D.
AU - Weintraub, S. J.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. Cells adhere to FN through integral membrane proteins that are members of the integrin family of adhesion molecules. The interaction between cells and FN is important in a number of biologic processes, including gastrulation, hematopoietic differentiation, neural crest cell migration, cardiac development, branching morphogenesis in lung, wound healing, tumorogenesis, and metastasis. Expression of FN and its receptors is controlled by a number of hormones and growth factors as well as by tissue-specific factors. Here, the molecular aspects of how expression of these genes is controlled are reviewed, with particular emphasis on promoter regulator elements that modulate expression.
AB - Fibronectin (FN) is an extracellular matrix protein that acts as a substrate for cell migration and adhesion during development. Cells adhere to FN through integral membrane proteins that are members of the integrin family of adhesion molecules. The interaction between cells and FN is important in a number of biologic processes, including gastrulation, hematopoietic differentiation, neural crest cell migration, cardiac development, branching morphogenesis in lung, wound healing, tumorogenesis, and metastasis. Expression of FN and its receptors is controlled by a number of hormones and growth factors as well as by tissue-specific factors. Here, the molecular aspects of how expression of these genes is controlled are reviewed, with particular emphasis on promoter regulator elements that modulate expression.
UR - http://www.scopus.com/inward/record.url?scp=1842318477&partnerID=8YFLogxK
M3 - Article
C2 - 1832529
AN - SCOPUS:1842318477
VL - 144
SP - S25-S28
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
SN - 0003-0805
IS - 3 II
ER -