Expression of an erythropoietin‐like gene in the trout

A. SHIELS, S. N. WICKRAMASINGHE

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Cross‐species Northern blot hybridization and radioimmunoassay have provided evidence for the expression of an erythropoietin (EPO)‐like gene in the rainbow trout. The principal site of EPO‐like mRNA and antigen expression in the adult trout appears to be the kidney which also acts as the major erythropoietic organ. The data suggest that a locally produced EPO‐like factor may regulate renal erythropoiesis in bony fish and, furthermore, they identify a possible evolutionary origin for renal EPO production in mammals.

Original languageEnglish
Pages (from-to)219-221
Number of pages3
JournalBritish Journal of Haematology
Volume90
Issue number1
DOIs
StatePublished - May 1995

Keywords

  • erythropoietin
  • evolution
  • kidney
  • mRNA
  • trout

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