Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects

Keyphrases

• Transcriptional Repressor 100%
• Birth Defects 100%
• SALL1 100%
• Townes-Brocks Syndrome 100%
• Mouse Model 11%
• Null Mice 11%
• Mutant Protein 11%
• DNA-binding Domain 11%
• Family Members 11%
• Deformity 11%
• Multiple Organs 11%
• Dominant Negative 11%
• Renal Agenesis 11%
• Sudden Sensorineural Hearing Loss (SSNHL) 11%
• Transcriptional Repression 11%
• Mutant Mice 11%
• Abnormal Development 11%
• Gain-of-function 11%
• Haploinsufficiency 11%
• Normal Function 11%
• Functions Activities 11%
• Multiple Births 11%
• Bone Abnormalities 11%
• Null Allele 11%
• Truncated Protein 11%
• Mutant Alleles 11%
• Human Syndromes 11%
• Hypoplasia 11%
• Autosomal Dominant Disorder 11%
• Heterozygous Mice 11%
• Limb Malformation 11%
• Renal Malformations 11%
• Exencephaly 11%
• Ear Deformity 11%
• Wrist Bone 11%

Biochemistry, Genetics and Molecular Biology

• Transcriptional Repressor 100%
• SALL1 100%
• Knockout Mouse 33%
• Mouse Model 33%
• Mutant Protein 33%
• Allele 33%
• Autosomal Dominant Inheritance 33%
• DNA-binding Domain 33%
• Mouse Mutant 33%
• Haploinsufficiency 33%
• Null Allele 33%
• Exencephaly 33%