Objective To study the expression and prognostic significance of galectin-1 and galectin-3 in different melanocytic lesions. Methods The expression of galectin-1 and galectin-3 in 39 cases of benign nevus, 58 cases of primary cutaneous melanoma, 24 cases of primary mucosal melanoma, 69 cases of melanoma with lymph node metastasis and 8 cases of melanoma with distant metastasis were studied by immunohistochemistry and tissue microarray. Results The expression of galectin-1 and galectin-3 was higher in benign nevi than in melanomas ( P < 0. 01 ). The nuclear expression of galectin-3 was higher in primary cutaneous melanomas than in primary mucosal melanomas or melanomas with metastases (P <0. 01, respectively ). The expression correlated with age of patients ( P < 0. 05 ) , necrosis ( P < 0. 05 ) and survival time P<0. 01). Clark's level also correlated with survival time in patients with cutaneous melanomas (P = 0.037). TNM staging was the only independent prognostic factor for melanomas (P <0.01). Conclusions The expression of galectin-1 and galectin-3 is decreased in melanomas. The decrease in nuclear expression of galectin-3 may represent a poor prognostic factor for melanomas. TNM staging is an independent prognostic factor which influences the survival time.
|Number of pages||5|
|Journal||Chinese Journal of Pathology|
|State||Published - Dec 2013|