TY - JOUR
T1 - Exposure to ambient air pollution and blood lipids in adults
T2 - The 33 Communities Chinese Health Study
AU - Yang, Bo Yi
AU - Bloom, Michael S.
AU - Markevych, Iana
AU - Qian, Zhengmin (Min)
AU - Vaughn, Michael G.
AU - Cummings-Vaughn, Lenise A.
AU - Li, Shanshan
AU - Chen, Gongbo
AU - Bowatte, Gayan
AU - Perret, Jennifer L.
AU - Dharmage, Shyamali C.
AU - Heinrich, Joachim
AU - Yim, Steve Hung Lam
AU - Lin, Shao
AU - Tian, Linwei
AU - Yang, Mo
AU - Liu, Kang Kang
AU - Zeng, Xiao Wen
AU - Hu, Li Wen
AU - Guo, Yuming
AU - Dong, Guang Hui
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/10
Y1 - 2018/10
N2 - Background: Little information exists on the lipidemic effects of air pollution, particularly in developing countries. We aimed to investigate the associations of long-term exposure to ambient air pollutants with lipid levels and dyslipidemias in China. Methods: In 2009, a total of 15,477 participants aged 18–74 years were recruited from the 33 Communities Chinese Health Study conducted in three Northeastern China cities. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured in participants’ blood specimens. Three year (2006–08) average air pollution concentrations were assessed using data from 33 communities (particles with diameters ≤1.0 μm (PM1) and ≤2.5 μm (PM2.5) were predicted using a spatial statistical model) or 11 air monitoring stations (particles with diameters ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3)). Associations were evaluated by two-level logistic and generalized linear regression models. Results: We detected many significant associations between exposure to air pollutants (especially for PM1 and PM2.5) and blood lipid levels. Most of the associations suggested deleterious effects on blood lipid markers (e.g., a 10 μg/m3 increase in PM1 was associated with 1.6% (95% confidence interval (CI): 1.1, 2.0), 2.9% (95% CI: −3.3, 9.3), and 3.2% (95% CI: 2.6, 3.9) higher levels of TC, TG, and LDL-C, respectively, but 1.4% (95% CI: −1.8, −0.9) lower HDL-C levels), although beneficial associations were found for O3. In analysis with dyslipidemias, all the observed associations suggested deleterious lipidemic effects of air pollutants, and no significant beneficial association was observed for O3. Stratified analyses showed that the associations were stronger in overweight or obese participants; sex and age modified the associations, but the pattern of effects was mixed. Conclusions: Long-term ambient air pollution was associated with both altered lipid profiles and dyslipidemias, especially among overweight or obese participants.
AB - Background: Little information exists on the lipidemic effects of air pollution, particularly in developing countries. We aimed to investigate the associations of long-term exposure to ambient air pollutants with lipid levels and dyslipidemias in China. Methods: In 2009, a total of 15,477 participants aged 18–74 years were recruited from the 33 Communities Chinese Health Study conducted in three Northeastern China cities. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured in participants’ blood specimens. Three year (2006–08) average air pollution concentrations were assessed using data from 33 communities (particles with diameters ≤1.0 μm (PM1) and ≤2.5 μm (PM2.5) were predicted using a spatial statistical model) or 11 air monitoring stations (particles with diameters ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), and ozone (O3)). Associations were evaluated by two-level logistic and generalized linear regression models. Results: We detected many significant associations between exposure to air pollutants (especially for PM1 and PM2.5) and blood lipid levels. Most of the associations suggested deleterious effects on blood lipid markers (e.g., a 10 μg/m3 increase in PM1 was associated with 1.6% (95% confidence interval (CI): 1.1, 2.0), 2.9% (95% CI: −3.3, 9.3), and 3.2% (95% CI: 2.6, 3.9) higher levels of TC, TG, and LDL-C, respectively, but 1.4% (95% CI: −1.8, −0.9) lower HDL-C levels), although beneficial associations were found for O3. In analysis with dyslipidemias, all the observed associations suggested deleterious lipidemic effects of air pollutants, and no significant beneficial association was observed for O3. Stratified analyses showed that the associations were stronger in overweight or obese participants; sex and age modified the associations, but the pattern of effects was mixed. Conclusions: Long-term ambient air pollution was associated with both altered lipid profiles and dyslipidemias, especially among overweight or obese participants.
KW - Cross-sectional study
KW - Dyslipidemia
KW - Gaseous pollutants
KW - Lipids
KW - Particulate matter
UR - http://www.scopus.com/inward/record.url?scp=85050195236&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2018.07.016
DO - 10.1016/j.envint.2018.07.016
M3 - Article
C2 - 30048882
AN - SCOPUS:85050195236
SN - 0160-4120
VL - 119
SP - 485
EP - 492
JO - Environment International
JF - Environment International
ER -