Exposure of mice to live Pseudomonas aeruginosa generates protective cell-mediated immunity in the absence of an antibody response

R. B. Markham, W. G. Powderly

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In previous studies we have elicited T cell-mediated protective immunity to the extra-cellular gram-negative bacterium Pseudomonas aeruginosa by administering P. aeruginosa polysaccharide Ag and the anti-mitotic agent vinblastine sulfate to BALB/c mice. The current studies indicate that T cells which inhibit the growth of P. aeruginosa in vitro and protect granulocytopenic mice from P. aeruginosa infection can be generated by exposure of BALB/c mice to as few as 102 live bacteria without simultaneous administration of vinblastine. The in vitro inhibition of bacterial growth and mouse protection are P. aeruginosa immunotype specific. Exposure to 106 live bacteria is required to elicit a detectable antibody response. These findings indicate a potential role for T cells in resistance to P. aeruginosa infection in the large majority of individuals who lack anti-P. aeruginosa antibody.

Original languageEnglish
Pages (from-to)2039-2045
Number of pages7
JournalJournal of Immunology
Volume140
Issue number6
StatePublished - Jan 1 1988

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