TY - JOUR
T1 - Exploring the physiological correlates of chronic mild traumatic brain injury symptoms
AU - Astafiev, Serguei V.
AU - Zinn, Kristina L.
AU - Shulman, Gordon L.
AU - Corbetta, Maurizio
N1 - Funding Information:
This work was supported by a James S. McDonnell Foundation grant to the Attention Dynamics Consortium in Traumatic Brain Injury (ADC-TBI) and by the National Institute of Neurological Disorders (NINDS) grant R01 NS095741 . Serguei V. Astafiev, PhD was partially supported by funds from the Department of Neurology, Washington University in St. Louis .
Funding Information:
This work was supported by a James S. McDonnell Foundation grant to the Attention Dynamics Consortium in Traumatic Brain Injury (ADCTBI)and by the National Institute of Neurological Disorders (NINDS) grant R01 NS095741. Serguei V. Astafiev, PhD was partially supported by funds from the Department of Neurology, Washington University in St. Louis. We gratefully acknowledge Robert Fucetola PhD for neuropsychological consultation; A.Z. Snyder MD PhD for image analysis assistance; David L. Brody M.D. Ph.D. for referral of some mTBI subjects; and M.P. McAvoy PhD and M.J. Strube PhD for statistical advice.
Publisher Copyright:
© 2016 The Authors.
PY - 2016
Y1 - 2016
N2 - We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.
AB - We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.
KW - Behavioral assessments
KW - Diffusion tensor imaging
KW - MRI
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84955111072&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2016.01.004
DO - 10.1016/j.nicl.2016.01.004
M3 - Article
C2 - 26909324
AN - SCOPUS:84955111072
VL - 11
SP - 10
EP - 19
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
SN - 2213-1582
ER -