Exploring the architecture of potassium channels using chimeras to reveal signal transduction

Baron Chanda, J. K. Tiwari, Anurag Varshney, M. K. Mathew

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The chimaeric channel, 4N/1, generated from two outwardly rectifying K+ channels by linking the N-terminal cytoplasmic domain of hKv1.4 with the transmembrane body of hKv1.1, functions as an inward rectifier. The operating range of the channel is shifted to hyperpolarizing potentials and it is inactivated at resting membrane potentials. Coexpression of a truncated form of hKv1.1 with the N-terminal domain of hKv1.4 results in the same physiology as the chimera implying specific interactions between the two segments.

Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalBioscience Reports
Volume19
Issue number4
DOIs
StatePublished - 1999

Keywords

  • Chimaera
  • Ion channel
  • Ion selectivity
  • Voltage sensing

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