Exploring feature-based approaches in PET images for predicting cancer treatment outcomes

I. El Naqa, P. W. Grigsby, A. Apte, E. Kidd, E. Donnelly, D. Khullar, S. Chaudhari, D. Yang, M. Schmitt, Richard Laforest, W. L. Thorstad, J. O. Deasy

Research output: Contribution to journalArticlepeer-review

418 Scopus citations


Accumulating evidence suggests that characteristics of pre-treatment FDG-PET could be used as prognostic factors to predict outcomes in different cancer sites. Current risk analyses are limited to visual assessment or direct uptake value measurements. We are investigating intensity-volume histogram metrics and shape and texture features extracted from PET images to predict patient's response to treatment. These approaches were demonstrated using datasets from cervix and head and neck cancers, where AUC of 0.76 and 1.0 were achieved, respectively. The preliminary results suggest that the proposed approaches could potentially provide better tools and discriminant power for utilizing functional imaging in clinical prognosis.

Original languageEnglish
Pages (from-to)1162-1171
Number of pages10
JournalPattern Recognition
Issue number6
StatePublished - Jun 2009


  • Co-occurrence matrix
  • Image morphology
  • Intensity-volume histograms
  • Positron emission tomography
  • Treatment outcomes
  • Tumor heterogeneity
  • Tumor shape
  • Uptake values


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