TY - JOUR
T1 - Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index
AU - CVI.grid
AU - Agrawal, Rupesh
AU - Ding, Jianbin
AU - Sen, Parveen
AU - Rousselot, Andres
AU - Chan, Amy
AU - Nivison-Smith, Lisa
AU - Wei, Xin
AU - Mahajan, Sarakshi
AU - Kim, Ramasamy
AU - Mishra, Chitaranjan
AU - Agarwal, Manisha
AU - Suh, Min Hee
AU - Luthra, Saurabh
AU - Munk, Marion R.
AU - Cheung, Carol Y.
AU - Gupta, Vishali
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/7
Y1 - 2020/7
N2 - The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced inconsistent findings, partly due to the physical inaccessibility of the choroid and the lack of reliable biomarkers. With the advancements in optical coherence tomography technology, our group has developed a novel quantitative imaging biomarker known as the choroidal vascularity index (CVI), defined as the ratio of vascular area to the total choroidal area. CVI is a potential tool in establishing early diagnoses, monitoring disease progression and prognosticating patients. CVI has been reported in existing literature as a robust marker in numerous retinal and choroidal diseases. In this review, we will discuss the current role of CVI with reference to existing literature, and make postulations about its potential and future applications.
AB - The choroid is one of the most vascularized structures of the human body and plays an irreplaceable role in nourishing photoreceptors. As such, choroidal dysfunction is implicated in a multitude of ocular diseases. Studying the choroid can lead to a better understanding of disease pathogenesis, progression and discovery of novel management strategies. However, current research has produced inconsistent findings, partly due to the physical inaccessibility of the choroid and the lack of reliable biomarkers. With the advancements in optical coherence tomography technology, our group has developed a novel quantitative imaging biomarker known as the choroidal vascularity index (CVI), defined as the ratio of vascular area to the total choroidal area. CVI is a potential tool in establishing early diagnoses, monitoring disease progression and prognosticating patients. CVI has been reported in existing literature as a robust marker in numerous retinal and choroidal diseases. In this review, we will discuss the current role of CVI with reference to existing literature, and make postulations about its potential and future applications.
KW - Age related macular degeneration
KW - Artificial intelligence
KW - Choroid
KW - Choroidal vascularity index
KW - Optical coherence tomography
KW - Uveitis
UR - http://www.scopus.com/inward/record.url?scp=85077996654&partnerID=8YFLogxK
U2 - 10.1016/j.preteyeres.2020.100829
DO - 10.1016/j.preteyeres.2020.100829
M3 - Review article
C2 - 31927136
AN - SCOPUS:85077996654
SN - 1350-9462
VL - 77
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
M1 - 100829
ER -