Exploiting linkage disequilibrium in population isolates

R. Culverhouse, J. Lin, K. Liu, B. K. Suarez

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A comparison of haplotype frequencies between unrelated cases and controls from population isolates identifies a strong signal for the presence/absence of the discrete phenotype in an interval on chromosome 6 bounded by markers 34 and 35. We define a dissimilarity index, D, which is sensitive to differences in allele distributions and differences in the patterns of linkage disequilibrium between cases and controls. We describe two statistical methods to utilize D: A method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples.

Original languageEnglish
Pages (from-to)S429-S434
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
DOIs
StatePublished - 2001

Keywords

  • Case/control
  • Haplotypes
  • Linkage disequilibrium

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