TY - JOUR
T1 - Experimental models of lung transplantation
AU - Bribriesco, Alejandro Cano
AU - Li, Wenjun
AU - Nava, Ruben Guadalupe
AU - Spahn, Jessica Helen
AU - Kreisel, Daniel
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Lung transplantation is a life saving treatment for end stage pulmonary diseases. The development and refinement of this therapy required the utilization of various animal models, without which this procedure would not have become a clinical reality. Canine models were critical in the initial breakthroughs in surgical technique and immunosuppressive regimens, which directly led to the first successful human lung transplantation. Orthotopic lung transplant models in the rat provided a platform for more detailed investigation of immune responses to pulmonary grafts. Investigation of chronic rejection of lungs has significantly been advanced through the use of mouse tracheal transplant experiments. And finally, the advent of orthotopic, vascularized lung transplantation in the mouse opened the door to the use of genetic and molecular tools that are necessary for the rigorous mechanistic study of alloimmune and nonalloimmune factors contributing to lung graft failure. Taken together, animal models will continue to be a cornerstone in the advancement of clinical success in lung transplantation.
AB - Lung transplantation is a life saving treatment for end stage pulmonary diseases. The development and refinement of this therapy required the utilization of various animal models, without which this procedure would not have become a clinical reality. Canine models were critical in the initial breakthroughs in surgical technique and immunosuppressive regimens, which directly led to the first successful human lung transplantation. Orthotopic lung transplant models in the rat provided a platform for more detailed investigation of immune responses to pulmonary grafts. Investigation of chronic rejection of lungs has significantly been advanced through the use of mouse tracheal transplant experiments. And finally, the advent of orthotopic, vascularized lung transplantation in the mouse opened the door to the use of genetic and molecular tools that are necessary for the rigorous mechanistic study of alloimmune and nonalloimmune factors contributing to lung graft failure. Taken together, animal models will continue to be a cornerstone in the advancement of clinical success in lung transplantation.
KW - Animal models
KW - Dogs
KW - Experimental models
KW - Heterotopic
KW - Lung transplantation
KW - Mice
KW - Orthotopic
KW - Rats
KW - Review
KW - Swine
UR - http://www.scopus.com/inward/record.url?scp=84884308688&partnerID=8YFLogxK
U2 - 10.2741/e614
DO - 10.2741/e614
M3 - Article
C2 - 23276988
AN - SCOPUS:84884308688
SN - 1945-0494
VL - 5 E
SP - 266
EP - 272
JO - Frontiers in Bioscience - Elite
JF - Frontiers in Bioscience - Elite
IS - 1
ER -