Experimental models of lung transplantation

Alejandro Cano Bribriesco, Wenjun Li, Ruben Guadalupe Nava, Jessica Helen Spahn, Daniel Kreisel

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Lung transplantation is a life saving treatment for end stage pulmonary diseases. The development and refinement of this therapy required the utilization of various animal models, without which this procedure would not have become a clinical reality. Canine models were critical in the initial breakthroughs in surgical technique and immunosuppressive regimens, which directly led to the first successful human lung transplantation. Orthotopic lung transplant models in the rat provided a platform for more detailed investigation of immune responses to pulmonary grafts. Investigation of chronic rejection of lungs has significantly been advanced through the use of mouse tracheal transplant experiments. And finally, the advent of orthotopic, vascularized lung transplantation in the mouse opened the door to the use of genetic and molecular tools that are necessary for the rigorous mechanistic study of alloimmune and nonalloimmune factors contributing to lung graft failure. Taken together, animal models will continue to be a cornerstone in the advancement of clinical success in lung transplantation.

Original languageEnglish
Pages (from-to)266-272
Number of pages7
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Animal models
  • Dogs
  • Experimental models
  • Heterotopic
  • Lung transplantation
  • Mice
  • Orthotopic
  • Rats
  • Review
  • Swine

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