Experimental glomerulonephritis: VIII. The in vivo fixation of heterologous nephrotoxic antibodies to, and their exchange among, tissues of the rat

E. R. Unanue, F. J. Dixon, S. Lee

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6 Scopus citations

Abstract

The distribution of fixation of nephrotoxic antibodies and their subsequent exchange among the kidneys and non-renal tissue was studied in two experimental conditions. In the first, radioiodine labeled nephrotoxic gamma globulin was injected into rats which were then united by parabiosis to non-injected isologous rats. In the second, a kidney from a rat injected with labeled nephrotoxic gamma globulin was transplanted to an isologous rat. These experiments showed a continuous dissociation and reassociation of the antibodies following their initial fixation to the tissues. This exchange involved primarily the low avidity and specificity antibody in non-renal tissues and to a lesser extent the more avid kidney fixed antibodies.

Original languageEnglish
Pages (from-to)140-150
Number of pages11
JournalInternational Archives of Allergy and Immunology
Volume29
Issue number2
DOIs
StatePublished - 1966

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