Experience-dependent development of feedforward and feedback circuits between lower and higher areas of mouse visual cortex

Hongwei Dong, Quanxin Wang, Katia Valkova, Yuri Gonchar, Andreas Burkhalter

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Using whole cell recordings, we studied excitatory and inhibitory postsynaptic currents (EPSCs, IPSCs) in feedforward (FF) and feedback (FB) circuits between areas V1 and LM (lateromedial) in developing mouse visual cortex. We found that in mice reared with normal visual experience, FF and FB synapses onto layer 2/3 pyramidal neurons develop equal but submaximal strengths whose EPSCs are increased by monocular lid suture. In contrast, the development and experience-dependence of FF- and FB-IPSCs is pathway-specific. The difference develops during the critical period by strengthening FF-IPSCs, while keeping FB-IPSC amplitudes constant. Monocular lid suture increases FB-IPSCs but does not affect FF-IPSCs.

Original languageEnglish
Pages (from-to)3389-3400
Number of pages12
JournalVision Research
Volume44
Issue number28 SPEC.ISS.
DOIs
StatePublished - Dec 2004

Keywords

  • Cortical areas
  • Extrastriate cortex
  • Synaptic excitation
  • Synaptic inhibition

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