Exosomes, microvesicles, and other extracellular vesicles—a Keystone Symposia report

Jennifer Cable, Kenneth W. Witwer, Robert J. Coffey, Aleksandar Milosavljevic, Ariana K. von Lersner, Lizandra Jimenez, Ferdinando Pucci, Maureen M. Barr, Niek Dekker, Bahnisikha Barman, Daniel Humphrys, Justin Williams, Michele de Palma, Wei Guo, Nuno Bastos, Andrew F. Hill, Efrat Levy, Michael P. Hantak, Clair Crewe, Elena AikawaAlan M. Adamczyk, Tamires M. Zanotto, Matias Ostrowski, Tanina Arab, Daniel C. Rabe, Aadil Sheikh, Danilo Rodrigues da Silva, Jennifer C. Jones, Chioma Okeoma, Thomas Gaborski, Qin Zhang, Olesia Gololobova

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Extracellular vesicles (EVs) are small, lipid-bilayer-bound particles released by cells that can contain important bioactive molecules, including lipids, RNAs, and proteins. Once released in the extracellular environment, EVs can act as messengers locally as well as to distant tissues to coordinate tissue homeostasis and systemic responses. There is a growing interest in not only understanding the physiology of EVs as signaling particles but also leveraging them as minimally invasive diagnostic and prognostic biomarkers (e.g., they can be found in biofluids) and drug-delivery vehicles. On October 30–November 2, 2022, researchers in the EV field convened for the Keystone symposium “Exosomes, Microvesicles, and Other Extracellular Vesicles” to discuss developing standardized language and methodology, new data on the basic biology of EVs and potential clinical utility, as well as novel technologies to isolate and characterize EVs.

Original languageEnglish
Pages (from-to)24-37
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume1523
Issue number1
DOIs
StatePublished - May 2023

Keywords

  • exomere
  • exosome
  • extracellular RNA
  • extracellular vesicle
  • mitovesicle
  • supermere

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