Exome sequencing and the genetic basis of complex traits

Adam Kiezun; Kiran Garimella; Ron Do; Nathan O. Stitziel; Benjamin M. Neale; Paul J. McLaren; Namrata Gupta; Pamela Sklar; Patrick F. Sullivan; Jennifer L. Moran; Christina M. Hultman; Paul Lichtenstein; Patrik Magnusson; Thomas Lehner; Yin Yao Shugart; Alkes L. Price; Paul I.W. De Bakker; Shaun M. Purcell; Shamil R. Sunyaev

doi:10.1038/ng.2303

Exome sequencing and the genetic basis of complex traits

Adam Kiezun, Kiran Garimella, Ron Do, Nathan O. Stitziel, Benjamin M. Neale, Paul J. McLaren, Namrata Gupta, Pamela Sklar, Patrick F. Sullivan, Jennifer L. Moran, Christina M. Hultman, Paul Lichtenstein, Patrik Magnusson, Thomas Lehner, Yin Yao Shugart, Alkes L. Price, Paul I.W. De Bakker, Shaun M. Purcell, Shamil R. Sunyaev

Research output: Contribution to journal › Review article › peer-review

311 Scopus citations

Original language	English
Pages (from-to)	623-630
Number of pages	8
Journal	Nature Genetics
Volume	44
Issue number	6
DOIs	https://doi.org/10.1038/ng.2303
State	Published - Jun 2012

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Kiezun, A., Garimella, K., Do, R., Stitziel, N. O., Neale, B. M., McLaren, P. J., Gupta, N., Sklar, P., Sullivan, P. F., Moran, J. L., Hultman, C. M., Lichtenstein, P., Magnusson, P., Lehner, T., Shugart, Y. Y., Price, A. L., De Bakker, P. I. W., Purcell, S. M., & Sunyaev, S. R. (2012). Exome sequencing and the genetic basis of complex traits. Nature Genetics, 44(6), 623-630. https://doi.org/10.1038/ng.2303

@article{8124bfc69e084ce9ae6e446926b4c97e,

title = "Exome sequencing and the genetic basis of complex traits",

author = "Adam Kiezun and Kiran Garimella and Ron Do and Stitziel, {Nathan O.} and Neale, {Benjamin M.} and McLaren, {Paul J.} and Namrata Gupta and Pamela Sklar and Sullivan, {Patrick F.} and Moran, {Jennifer L.} and Hultman, {Christina M.} and Paul Lichtenstein and Patrik Magnusson and Thomas Lehner and Shugart, {Yin Yao} and Price, {Alkes L.} and {De Bakker}, {Paul I.W.} and Purcell, {Shaun M.} and Sunyaev, {Shamil R.}",

note = "Funding Information: The authors are grateful to S. Pollack for assistance with EIGENSOFT. This work was made possible, in part, by the US National Institutes of Health (NIH; grant 5R01 MH084676) and, in part, by the International HIV Controllers Study, supported by the Collaboration for AIDS Vaccine Discovery of the Bill and Melinda Gates Foundation (to P.I.W.d.B.), and the AIDS Clinical Trials Group, supported by the NIH (grants AI069513, AI34835, AI069432, AI069423, AI069477, AI069501, AI069474, AI069428, AI69467, AI069415, Al32782, AI27661, AI25859, AI28568, AI30914, AI069495, AI069471, AI069532, AI069452, AI069450, AI069556, AI069484, AI069472, AI34853, AI069465, AI069511, AI38844, AI069424, AI069434, AI46370, AI68634, AI069502, AI069419, AI068636, RR024975 and AI077505). Sequencing of the SCZ control individuals was funded by the NIH (grant RC2MH089905), the Herman Foundation and the Stanley Medical Research Institute. N.O.S. was supported, in part, by an NIH Training Grant (T32-HL07604-25; Division of Cardiovascular Medicine, Brigham and Women{\textquoteright}s Hospital). B.M.N. was supported by a National Institute of Mental Health (NIMH) grant (1R01MH089208-01). R.D. is supported by a Canadian Institutes of Health Research Banting Postdoctoral Fellowship. The views expressed in this paper do not necessarily represent the views of the NIMH, NIH, Department of Health and Human Services (HHS) or the US government.",

year = "2012",

month = jun,

doi = "10.1038/ng.2303",

language = "English",

volume = "44",

pages = "623--630",

journal = "Nature Genetics",

issn = "1061-4036",

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Kiezun, A, Garimella, K, Do, R, Stitziel, NO, Neale, BM, McLaren, PJ, Gupta, N, Sklar, P, Sullivan, PF, Moran, JL, Hultman, CM, Lichtenstein, P, Magnusson, P, Lehner, T, Shugart, YY, Price, AL, De Bakker, PIW, Purcell, SM & Sunyaev, SR 2012, 'Exome sequencing and the genetic basis of complex traits', Nature Genetics, vol. 44, no. 6, pp. 623-630. https://doi.org/10.1038/ng.2303

TY - JOUR

T1 - Exome sequencing and the genetic basis of complex traits

AU - Kiezun, Adam

AU - Garimella, Kiran

AU - Do, Ron

AU - Stitziel, Nathan O.

AU - Neale, Benjamin M.

AU - McLaren, Paul J.

AU - Gupta, Namrata

AU - Sklar, Pamela

AU - Sullivan, Patrick F.

AU - Moran, Jennifer L.

AU - Hultman, Christina M.

AU - Lichtenstein, Paul

AU - Magnusson, Patrik

AU - Lehner, Thomas

AU - Shugart, Yin Yao

AU - Price, Alkes L.

AU - De Bakker, Paul I.W.

AU - Purcell, Shaun M.

AU - Sunyaev, Shamil R.

N1 - Funding Information: The authors are grateful to S. Pollack for assistance with EIGENSOFT. This work was made possible, in part, by the US National Institutes of Health (NIH; grant 5R01 MH084676) and, in part, by the International HIV Controllers Study, supported by the Collaboration for AIDS Vaccine Discovery of the Bill and Melinda Gates Foundation (to P.I.W.d.B.), and the AIDS Clinical Trials Group, supported by the NIH (grants AI069513, AI34835, AI069432, AI069423, AI069477, AI069501, AI069474, AI069428, AI69467, AI069415, Al32782, AI27661, AI25859, AI28568, AI30914, AI069495, AI069471, AI069532, AI069452, AI069450, AI069556, AI069484, AI069472, AI34853, AI069465, AI069511, AI38844, AI069424, AI069434, AI46370, AI68634, AI069502, AI069419, AI068636, RR024975 and AI077505). Sequencing of the SCZ control individuals was funded by the NIH (grant RC2MH089905), the Herman Foundation and the Stanley Medical Research Institute. N.O.S. was supported, in part, by an NIH Training Grant (T32-HL07604-25; Division of Cardiovascular Medicine, Brigham and Women’s Hospital). B.M.N. was supported by a National Institute of Mental Health (NIMH) grant (1R01MH089208-01). R.D. is supported by a Canadian Institutes of Health Research Banting Postdoctoral Fellowship. The views expressed in this paper do not necessarily represent the views of the NIMH, NIH, Department of Health and Human Services (HHS) or the US government.

PY - 2012/6

Y1 - 2012/6

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U2 - 10.1038/ng.2303

DO - 10.1038/ng.2303

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AN - SCOPUS:84861618864

SN - 1061-4036

VL - 44

SP - 623

EP - 630

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Exome sequencing and the genetic basis of complex traits

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