Exogenous NT-3 mitigates the transganglionic neuropeptide Y response to sciatic nerve injury

Shinji Ohara, Vrijesh Tantuwaya, Peter S. DiStefano, Robert E. Schmidt

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Peripheral sciatic nerve transection injury produces a marked increase in immunoreactive NPY in rat lumbar DRG and, as a 'transganglionic' response, in their central axonal projections to the dorsal spinal cord and gracile nuclei. Local application of neurotrophin-3 (NT-3) using implanted silicone chambers applied to the proximal transected sciatic nerve stump significantly diminished the transganglionic NPY response in the gracile nucleus and spinal cord but did not affect the CGRP transganglionic response. Conversely, local application of NGF affected the transganglionic CGRP response to axotomy but did not substantially affect transganglionic gracile NPY upregulation.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalBrain Research
Volume699
Issue number1
DOIs
StatePublished - Nov 13 1995

Keywords

  • Growth factor
  • Neuropathy
  • Neuropeptide
  • Neurotrophin

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