TY - JOUR
T1 - Exercise training reduces central adiposity and improves metabolic indices in HAART-treated HIV-positive subjects in Rwanda
T2 - A randomized controlled trial
AU - Mutimura, Eugene
AU - Crowther, Nigel J.
AU - Cade, Todd W.
AU - Yarasheski, Kevin E.
AU - Stewart, Aimee
PY - 2008/1/1
Y1 - 2008/1/1
N2 - As HAART becomes more accessible in sub-Saharan Africa, metabolic syndromes, body fat redistribution (BFR), and cardiovascular disease may become more prevalent. We conducted a 6-month, randomized controlled trial to test whether cardiorespiratory exercise training (CET), improves metabolic, body composition and cardiorespiratory fitness parameters in HAART-treated HIV + African subjects with BFR. Six months of CET reduced waist circumference (-7.13 ± 4.4 cm, p < 0.0001), WHR (-0.10 ± 0.1, p < 0.0001), sum skinfold thickness (-6.15 ± 8.2 mm, p < 0.0001) and % body fat mass (-1.5 ± 3.3, p < 0.0001) in HIV+BFR +EXS. Hip circumference was unchanged in non-exercise control groups. CET reduced fasting total cholesterol (-0.03 ± 1.11 mM, p < 0.05), triglycerides (-0.22 ±0.48 mM, p < 0.05) and glucose levels (-0.21 ± 0.71 mM, p < 0.05) (p < 0.0001). HDL-, LDL-cholesterol and HOMA values were unchanged after CET. Interestingly, HIV+ subjects randomized to non-exercising groups experienced increases in fasting plasma glucose levels, whereas HIV seronegative controls did not (p < 0.001). Predicted VO2 peak increased more in the HIV+BFR +EXS than in all other groups (4.7 ± 3.9 ml/kg/min, p < 0.0001). Exercise training positively modulated body composition and metabolic profiles, and improved cardiorespiratory fitness in HAART-treated HIV + Africans. These beneficial adaptations imply that exercise training is a safe, inexpensive, practical, and effective treatment for evolving metabolic and cardiovascular syndromes associated with HIV and HAART exposure in resource-limited sub-Saharan countries, where treatment is improving, morbidity and mortality rates are declining, but where minimal resources are available to manage HIVand HAART-associated cardiovascular and metabolic syndromes.
AB - As HAART becomes more accessible in sub-Saharan Africa, metabolic syndromes, body fat redistribution (BFR), and cardiovascular disease may become more prevalent. We conducted a 6-month, randomized controlled trial to test whether cardiorespiratory exercise training (CET), improves metabolic, body composition and cardiorespiratory fitness parameters in HAART-treated HIV + African subjects with BFR. Six months of CET reduced waist circumference (-7.13 ± 4.4 cm, p < 0.0001), WHR (-0.10 ± 0.1, p < 0.0001), sum skinfold thickness (-6.15 ± 8.2 mm, p < 0.0001) and % body fat mass (-1.5 ± 3.3, p < 0.0001) in HIV+BFR +EXS. Hip circumference was unchanged in non-exercise control groups. CET reduced fasting total cholesterol (-0.03 ± 1.11 mM, p < 0.05), triglycerides (-0.22 ±0.48 mM, p < 0.05) and glucose levels (-0.21 ± 0.71 mM, p < 0.05) (p < 0.0001). HDL-, LDL-cholesterol and HOMA values were unchanged after CET. Interestingly, HIV+ subjects randomized to non-exercising groups experienced increases in fasting plasma glucose levels, whereas HIV seronegative controls did not (p < 0.001). Predicted VO2 peak increased more in the HIV+BFR +EXS than in all other groups (4.7 ± 3.9 ml/kg/min, p < 0.0001). Exercise training positively modulated body composition and metabolic profiles, and improved cardiorespiratory fitness in HAART-treated HIV + Africans. These beneficial adaptations imply that exercise training is a safe, inexpensive, practical, and effective treatment for evolving metabolic and cardiovascular syndromes associated with HIV and HAART exposure in resource-limited sub-Saharan countries, where treatment is improving, morbidity and mortality rates are declining, but where minimal resources are available to manage HIVand HAART-associated cardiovascular and metabolic syndromes.
UR - http://www.scopus.com/inward/record.url?scp=38149109998&partnerID=8YFLogxK
U2 - 10.1089/aid.2007.0023
DO - 10.1089/aid.2007.0023
M3 - Article
C2 - 18275343
AN - SCOPUS:38149109998
VL - 24
SP - 15
EP - 23
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 1
ER -