TY - JOUR
T1 - Exercise training improves lipoprotein lipid profiles in patients with coronary artery disease
AU - Heath, Gregory W.
AU - Ehsani, Ali A.
AU - Hagberg, James M.
AU - Hinderliter, Judith M.
AU - Goldberg, Andrew P.
N1 - Funding Information:
From the Departments of Medicine and Hematology/Oncology, University the Veterans Administration Medical Supported by a Grant-In-Aid tion, Florida
PY - 1983/6
Y1 - 1983/6
N2 - The effects of endurance exercise training on plasma lipoprotein lipids were determined in 10 men, ages 46 to 62 years, with coronary artery disease (CAD). Patients maintained body weight, health-related behaviors, and stable diets throughout the program. Training was at 50% to 85% of maximal oxygen consumption (V̇O2 max) for 40 to 60 minutes, 3 to 5 days/week for 29 ± 7 weeks. Training increased V̇O2 max (31 ± 19%, p < 0.001), reduced plasma cholesterol (C) (-8 ± 4%, p < 0.01), low-density lipoprotein-C (LDL-C) (-9 ± 9%, p < 0.01), and triglyceride (TG) (-13 ± 32%, p < 0.05) concentrations, and increased high-density lipoprotein-C (HDL-C) levels (11 ± 13%, p < 0.05) and HDL-C LDL-C ratios (25 ± 20%, p < 0.01). Changes in LDL-C and V̇O2 max were correlated (r = -0.73, p ± 0.01), while the changes in LDL-C and HDL-C each correlated inversely with pretraining lipoprotein levels (rLDL-C = -0.77, p < 0.01; rHDL-C = -0.68, p < 0.05). Thus potentially "antiatherogenic" benefits of exercise seem to be due to a training effect, since they correlate best with changes in V̇O2 max and are maximal in patients with initially low V̇O2 max, high LDL-C, and low HDL-C levels.
AB - The effects of endurance exercise training on plasma lipoprotein lipids were determined in 10 men, ages 46 to 62 years, with coronary artery disease (CAD). Patients maintained body weight, health-related behaviors, and stable diets throughout the program. Training was at 50% to 85% of maximal oxygen consumption (V̇O2 max) for 40 to 60 minutes, 3 to 5 days/week for 29 ± 7 weeks. Training increased V̇O2 max (31 ± 19%, p < 0.001), reduced plasma cholesterol (C) (-8 ± 4%, p < 0.01), low-density lipoprotein-C (LDL-C) (-9 ± 9%, p < 0.01), and triglyceride (TG) (-13 ± 32%, p < 0.05) concentrations, and increased high-density lipoprotein-C (HDL-C) levels (11 ± 13%, p < 0.05) and HDL-C LDL-C ratios (25 ± 20%, p < 0.01). Changes in LDL-C and V̇O2 max were correlated (r = -0.73, p ± 0.01), while the changes in LDL-C and HDL-C each correlated inversely with pretraining lipoprotein levels (rLDL-C = -0.77, p < 0.01; rHDL-C = -0.68, p < 0.05). Thus potentially "antiatherogenic" benefits of exercise seem to be due to a training effect, since they correlate best with changes in V̇O2 max and are maximal in patients with initially low V̇O2 max, high LDL-C, and low HDL-C levels.
UR - http://www.scopus.com/inward/record.url?scp=0020614142&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(83)90385-X
DO - 10.1016/0002-8703(83)90385-X
M3 - Article
C2 - 6858834
AN - SCOPUS:0020614142
SN - 0002-8703
VL - 105
SP - 889
EP - 895
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -