TY - JOUR
T1 - Exercise training decreases plasma cholesteryl ester transfer protein
AU - Seip, R. L.
AU - Moulin, P.
AU - Cocke, T.
AU - Tall, A.
AU - Kohrt, W. M.
AU - Mankowitz, K.
AU - Semenkovich, C. F.
AU - Ostlund, R.
AU - Schonfeld, G.
PY - 1993
Y1 - 1993
N2 - To assess the effect of exercise on the plasma concentration of cholesterol ester transfer protein (CETP) and its possible influence in mediating the exercise-associated redistribution of cholesterol among plasma lipoproteins, we measured plasma CETP in 57 healthy normolipidemic men and women before and after 9 to 12 months of exercise training. The training protocol resulted in significant changes in Vo2max (mean±SD, +53±3.5 mL · kg-1 · min-1), body weight (-2.5±3.5 kg), plasma triglycerides (-25.7±36.3 mg/dL), high-density lipoprotein cholesterol (HDL-C) (+2.6±6.2 mg/dL), and ratios of total cholesterol to HDL-C (-0.30±0.52) and low-density lipoprotein cholesterol (LDL-C) to HDL-C (-0.18±0.45) (all P≤.05) but no change in lipoprotein(a). CETP concentration (in milligrams per liter) fell significantly in response to training in both men (n=28, 2.47±0.66 to 2.12±0.43; % Δ=14.2%; P<.005) and women (n=29, 2.72±1.01 to 2.36±0.76; % Δ=13.2%; P<.047). The CETP change was observed both in subjects who lost weight (n=28, Δ mean weight=-5.0 kg; Δ CETP=-0.42±0.79; % Δ=15.4%; P<.009) and in those who were weight stable (n=29, Δ mean weight=-0.12 kg; Δ CETP=-0.29±0.78; % Δ=10.4%; P<.055). Pretraining plasma CETP concentration predicted training-associated changes in HDL-C (r=-.27, P<.04) and ratio of LDL-C to HDL-C (r=+.40, P<.002). In a smaller study of 15 men, exercise training was associated with a decrease in levels of CETP, an increase in plasma postheparin lipoprotein lipase (LPL) activity, and a decrease in hepatic triglyceride lipase (HTGL) activity. Overall, the data suggest that basal plasma CETP concentrations, in addition to LPL and HTGL activities, may contribute to determining the extent to which exercise redistributes cholesterol among plasma lipoproteins.
AB - To assess the effect of exercise on the plasma concentration of cholesterol ester transfer protein (CETP) and its possible influence in mediating the exercise-associated redistribution of cholesterol among plasma lipoproteins, we measured plasma CETP in 57 healthy normolipidemic men and women before and after 9 to 12 months of exercise training. The training protocol resulted in significant changes in Vo2max (mean±SD, +53±3.5 mL · kg-1 · min-1), body weight (-2.5±3.5 kg), plasma triglycerides (-25.7±36.3 mg/dL), high-density lipoprotein cholesterol (HDL-C) (+2.6±6.2 mg/dL), and ratios of total cholesterol to HDL-C (-0.30±0.52) and low-density lipoprotein cholesterol (LDL-C) to HDL-C (-0.18±0.45) (all P≤.05) but no change in lipoprotein(a). CETP concentration (in milligrams per liter) fell significantly in response to training in both men (n=28, 2.47±0.66 to 2.12±0.43; % Δ=14.2%; P<.005) and women (n=29, 2.72±1.01 to 2.36±0.76; % Δ=13.2%; P<.047). The CETP change was observed both in subjects who lost weight (n=28, Δ mean weight=-5.0 kg; Δ CETP=-0.42±0.79; % Δ=15.4%; P<.009) and in those who were weight stable (n=29, Δ mean weight=-0.12 kg; Δ CETP=-0.29±0.78; % Δ=10.4%; P<.055). Pretraining plasma CETP concentration predicted training-associated changes in HDL-C (r=-.27, P<.04) and ratio of LDL-C to HDL-C (r=+.40, P<.002). In a smaller study of 15 men, exercise training was associated with a decrease in levels of CETP, an increase in plasma postheparin lipoprotein lipase (LPL) activity, and a decrease in hepatic triglyceride lipase (HTGL) activity. Overall, the data suggest that basal plasma CETP concentrations, in addition to LPL and HTGL activities, may contribute to determining the extent to which exercise redistributes cholesterol among plasma lipoproteins.
KW - Apolipoproteins
KW - Body composition
KW - Exercise training
KW - Glucose tolerance
KW - Insulin
KW - Lipoprotein(a)
KW - Mmaximal oxygen uptake
KW - Percent body fat
UR - http://www.scopus.com/inward/record.url?scp=0027169921&partnerID=8YFLogxK
M3 - Article
C2 - 8364020
AN - SCOPUS:0027169921
SN - 1079-5642
VL - 13
SP - 1359
EP - 1367
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 9
ER -