TY - JOUR
T1 - Exercise training and plasma catecholamines in patients with ischemic heart disease
AU - Cooksey, Jon D.
AU - Reilly, Patricia
AU - Brown, Sandra
AU - Bomze, Howard
AU - Cryer, Philip E.
N1 - Funding Information:
From the Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia and Departments of Preventive Medicine and Medicine, Washington University School of Medicine, Saint Louis, Missouri. This study was supported in part by a grant from the Missouri Heart Association. Manuscript received October 31, 1977; revised manuscript received April 11, 1978, accepted April 12, 1978. Address for reprints: Jon D. Cooksey, MD, Marshall Universitv School of Medicine. Huntino-ton, West Virginia-25701.
PY - 1978/9
Y1 - 1978/9
N2 - A 3 month program of exercise training was carried out in 10 patients with ischemic heart disease to assess the contribution of catecholamines to the training effect of improved exercise capacity and enhanced myocardlal oxygen delivery. Training resulted in a significant increase in maximal treadmill exercise time (mean ± standard error of the mean 374 ± 28 versus 567 ± 33 seconds, P < 0.0001). The heart rate-arterial pressure product, an index of myocardial oxygen consumption, was decreased at rest and at all levels of exercise after training. After training, the mean plasma norepinephrine level during supine rest was reduced (320 ± 23 to 191 ± 20 pg/ml, P < 0.01) and plasma epinephrine values were unchanged. When these previously sedentary patients exercised on a treadmill to the maximal level attained before exercise training, the mean plasma norepinephrine and plasma epinephrine concentrations were significantly reduced. These data suggest that the beneficial adaptations of the cardiovascular system to exercise training are at least partially mediated by changes in the catecholamine response to exercise.
AB - A 3 month program of exercise training was carried out in 10 patients with ischemic heart disease to assess the contribution of catecholamines to the training effect of improved exercise capacity and enhanced myocardlal oxygen delivery. Training resulted in a significant increase in maximal treadmill exercise time (mean ± standard error of the mean 374 ± 28 versus 567 ± 33 seconds, P < 0.0001). The heart rate-arterial pressure product, an index of myocardial oxygen consumption, was decreased at rest and at all levels of exercise after training. After training, the mean plasma norepinephrine level during supine rest was reduced (320 ± 23 to 191 ± 20 pg/ml, P < 0.01) and plasma epinephrine values were unchanged. When these previously sedentary patients exercised on a treadmill to the maximal level attained before exercise training, the mean plasma norepinephrine and plasma epinephrine concentrations were significantly reduced. These data suggest that the beneficial adaptations of the cardiovascular system to exercise training are at least partially mediated by changes in the catecholamine response to exercise.
UR - http://www.scopus.com/inward/record.url?scp=0018117881&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(78)90930-X
DO - 10.1016/0002-9149(78)90930-X
M3 - Article
C2 - 685849
AN - SCOPUS:0018117881
VL - 42
SP - 372
EP - 376
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 3
ER -