Exercise right heart catheterization for pulmonary hypertension identified on screening echocardiography in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort

Gregory T. Armstrong, James J. Tolle, Robert Piana, Aimee Santucci, James Leathers, Kirsten K. Ness, Daniel A. Mulrooney, Daniel M. Green, Vijaya M. Joshi, Leslie L. Robison, Melissa M. Hudson, Daniel Lenihan

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3 Scopus citations

Abstract

Pulmonary hypertension, determined noninvasively by tricuspid regurgitant jet velocity on Doppler echocardiography, was previously identified in 25% of long-term survivors who received chest-directed radiotherapy. To validate noninvasively defined pulmonary hypertension, survivors (mean age 48 years), exposed to chest radiotherapy, underwent right heart catheterization with planned cardiopulmonary exercise testing during catheterization. Eight participants had an elevated mean pulmonary artery pressure at rest (≥25 mm Hg) or with subsequent exercise (>30 mm Hg), evidence of hemodynamically confirmed pulmonary hypertension by right heart catheterization. Cardiopulmonary exercise testing further defined the magnitude and etiology of cardiopulmonary limitations in this life-threatening late effect.

Original languageEnglish
Article numbere26769
JournalPediatric Blood and Cancer
Volume65
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

Keywords

  • cancer
  • exercise
  • pediatric
  • pulmonary hypertension
  • survivor

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    Armstrong, G. T., Tolle, J. J., Piana, R., Santucci, A., Leathers, J., Ness, K. K., Mulrooney, D. A., Green, D. M., Joshi, V. M., Robison, L. L., Hudson, M. M., & Lenihan, D. (2018). Exercise right heart catheterization for pulmonary hypertension identified on screening echocardiography in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. Pediatric Blood and Cancer, 65(1), [e26769]. https://doi.org/10.1002/pbc.26769