TY - JOUR
T1 - Exercise moderates age-related atrophy of the medial temporal lobe
AU - Bugg, Julie M.
AU - Head, Denise
N1 - Funding Information:
The authors and their institution have no conflicts of interest related to this work. The sources of financial support were NIH grants P50 AG05861, P01 AG03991, and NIA grant 5T32AG00030. The data contained in this manuscript have not previously been published, nor has the manuscript been submitted elsewhere, nor will it be submitted elsewhere while under review. Appropriate ethical guidelines were followed with regard to the treatment of human subjects. All authors have reviewed the manuscript and approve of its contents and validate the accuracy of the data.
Funding Information:
We thank the Clinical Core of the Washington University Alzheimer Disease Research Center for the clinical assessments and the Imaging Core for the structural MRI data. We thank Lauren Ruth, Marlisa Isom, Becky Fierberg, Matt Riedel, Lindsay Casmaer, and William Janes for assistance with this project. Supported by NIH Grants P50 AG05861, P01 AG03991. Julie Bugg was supported by National Institute on Aging Grant 5T32AG00030.
PY - 2011/3
Y1 - 2011/3
N2 - Regional deterioration of brain structure is a typical feature of aging, but emerging evidence suggests that exercise may mitigate the decline. The purpose of the present investigation was to examine the moderating influence of exercise engagement on cross-sectional estimates of age-related brain atrophy at both global and regional levels. Estimates of exercise engagement over the past 10 years and MRI-based measures of global (gray and white) and regional volumes were obtained in a sample of 52 healthy older adults aged 55-79. Volume estimates were obtained in prefrontal, parietal, temporal, occipital, neostriatal, and medial temporal regions. Higher levels of exercise engagement were related to larger superior frontal volumes. Most critically, exercise engagement selectively moderated age-related medial temporal lobe atrophy. Specifically, significant age-related atrophy was observed for older adults who engaged in low levels of exercise, but not for those who engaged in high levels of exercise. This novel finding extends support for the efficacy of exercise to the potential maintenance of medial temporal lobe integrity in older adults.
AB - Regional deterioration of brain structure is a typical feature of aging, but emerging evidence suggests that exercise may mitigate the decline. The purpose of the present investigation was to examine the moderating influence of exercise engagement on cross-sectional estimates of age-related brain atrophy at both global and regional levels. Estimates of exercise engagement over the past 10 years and MRI-based measures of global (gray and white) and regional volumes were obtained in a sample of 52 healthy older adults aged 55-79. Volume estimates were obtained in prefrontal, parietal, temporal, occipital, neostriatal, and medial temporal regions. Higher levels of exercise engagement were related to larger superior frontal volumes. Most critically, exercise engagement selectively moderated age-related medial temporal lobe atrophy. Specifically, significant age-related atrophy was observed for older adults who engaged in low levels of exercise, but not for those who engaged in high levels of exercise. This novel finding extends support for the efficacy of exercise to the potential maintenance of medial temporal lobe integrity in older adults.
KW - Aging
KW - Brain atrophy
KW - Exercise
KW - Fitness
KW - Hippocampus
UR - https://www.scopus.com/pages/publications/77956353890
U2 - 10.1016/j.neurobiolaging.2009.03.008
DO - 10.1016/j.neurobiolaging.2009.03.008
M3 - Article
C2 - 19386382
AN - SCOPUS:77956353890
SN - 0197-4580
VL - 32
SP - 506
EP - 514
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 3
ER -