Exercise and the Marfan syndrome

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The Marfan syndrome is a heritable disorder of connective tissue affecting approximately one in 5000 to one in 10,000 individuals. The manifestations of the Marfan syndrome primarily involve the cardiovascular, musculoskeletal, and ocular systems. Aortic dilatation and dissection are the major causes of morbidity and mortality in the Marfan syndrome. The person with Marfan syndrome is often tall and agile and may unknowingly participate in certain physical activities and sports, putting himself or herself at risk for aortic dissection and sudden death. With appropriate diagnosis and treatment, the person with the Marfan syndrome can expect to live a long life. This article will review the diagnosis, genetics, clinical manifestations, and medical and surgical management of the Marfan syndrome. Guidelines for physical activity and exercise for the person with Marfan syndrome will be presented.

Original languageEnglish
Pages (from-to)S387-S395
JournalMedicine and Science in Sports and Exercise
Issue number10 SUPPL.
StatePublished - Oct 1998


  • Aortic aneurysm
  • Aortic dissection
  • Genetic disorder
  • Heart disease
  • Marfan syndrome
  • Physical activity
  • Sports


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