TY - JOUR
T1 - Excitotoxic neuronal damage and neuropsychiatric disorders
AU - Zorumski, Charles F.
AU - Olney, John W.
N1 - Funding Information:
Acknowledgements--This work was supported in part by NIMH Research Scientist Development Award MH00964 (CFZ), NIMH Research Scientist Award MH38894 (JWO) and grants AG05681 and MH45493.
PY - 1993
Y1 - 1993
N2 - Excitatory amino acids (EAA) serve important physiological functions in the vertebrate CNS, including participation in fast excitatory synaptic transmission, modulation of synaptic plasticity and regulation of neuronal morphology during development. However, paradoxically they also harbor neurotoxic (excitotoxic) potential, which, if unleashed, can cause widespread degeneration of CNS neurons. Accumulating evidence suggests a role for excitotoxins in a variety of human neuropsychiatric disorders. This paper reviews the classes of EAA receptors in the CNS, the mechanisms underlying EAA-mediated neuronal damage and the role of EAA in specific human disorders.
AB - Excitatory amino acids (EAA) serve important physiological functions in the vertebrate CNS, including participation in fast excitatory synaptic transmission, modulation of synaptic plasticity and regulation of neuronal morphology during development. However, paradoxically they also harbor neurotoxic (excitotoxic) potential, which, if unleashed, can cause widespread degeneration of CNS neurons. Accumulating evidence suggests a role for excitotoxins in a variety of human neuropsychiatric disorders. This paper reviews the classes of EAA receptors in the CNS, the mechanisms underlying EAA-mediated neuronal damage and the role of EAA in specific human disorders.
UR - http://www.scopus.com/inward/record.url?scp=0027525354&partnerID=8YFLogxK
U2 - 10.1016/0163-7258(93)90043-D
DO - 10.1016/0163-7258(93)90043-D
M3 - Review article
C2 - 7904075
AN - SCOPUS:0027525354
VL - 59
SP - 145
EP - 162
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
SN - 0163-7258
IS - 2
ER -