Abstract
Horizontal cells in the mudpuppy eyecup responded to continuous superfusion with l-gluamate, l-aspartate, kainate and quisqualate with a transient depolarization and reduction of the light evoked responses. However, in isolated retina preparations, in which these substances were applied to the photoreceptor side of the retina, the effects were sustained as long as the agonists were present. These results suggest that the transient action of these agonists in eyecup preparations was due to the rapid development of an intraretinal diffusion barrier, and are consistent with the hypothesis that photoreceptors release an excitatory amino acid transmitter.
Original language | English |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | Vision Research |
Volume | 27 |
Issue number | 2 |
DOIs | |
State | Published - 1987 |
Keywords
- Aspartate
- Glutamate
- Horizontal cells
- Kainate
- Mudpuppy Synaptic transmission
- Quisqualate
- Retina