Excitatory amino acids have different effects on horizontal cells in eyecup and isolated retina

Ei Ichi Miyachi, Peter D. Lukasiewicz, John S. McReynolds

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Horizontal cells in the mudpuppy eyecup responded to continuous superfusion with l-gluamate, l-aspartate, kainate and quisqualate with a transient depolarization and reduction of the light evoked responses. However, in isolated retina preparations, in which these substances were applied to the photoreceptor side of the retina, the effects were sustained as long as the agonists were present. These results suggest that the transient action of these agonists in eyecup preparations was due to the rapid development of an intraretinal diffusion barrier, and are consistent with the hypothesis that photoreceptors release an excitatory amino acid transmitter.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalVision Research
Volume27
Issue number2
DOIs
StatePublished - 1987

Keywords

  • Aspartate
  • Glutamate
  • Horizontal cells
  • Kainate
  • Mudpuppy Synaptic transmission
  • Quisqualate
  • Retina

Fingerprint

Dive into the research topics of 'Excitatory amino acids have different effects on horizontal cells in eyecup and isolated retina'. Together they form a unique fingerprint.

Cite this