TY - JOUR
T1 - Excessive daytime sleepiness is associated with changes in salivary inflammatory genes transcripts
AU - Thimgan, Matthew S.
AU - Toedebusch, Cristina
AU - McLeland, Jennifer
AU - Duntley, Stephen P.
AU - Shaw, Paul J.
N1 - Publisher Copyright:
© 2015 Matthew S. Thimgan et al.
PY - 2015
Y1 - 2015
N2 - Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A test that can reliably identify individuals that suffer from EDS is needed. In contrast to other methods, salivary biomarkers are an objective, inexpensive, and noninvasive method to identify individuals with inadequate sleep. Although we have previously shown that inflammatory genes are elevated in saliva samples taken from sleep deprived individuals, it is unclear if inflammatory genes will be elevated in clinical populations with EDS. In this study, salivary samples from individuals with sleep apnea were evaluated using the Taqman low density inflammation array. Transcript levels for 3 genes, including prostaglandin-endoperoxide synthase 2 (PTGS2), were elevated in patients with sleep apnea. Interestingly, PTGS2 was also elevated in patients with EDS but who did not have sleep apnea. These data demonstrate the feasibility of using salivary transcript levels to identify individuals that self-report excessive daytime sleepiness.
AB - Excessive daytime sleepiness (EDS) is a ubiquitous problem that affects public health and safety. A test that can reliably identify individuals that suffer from EDS is needed. In contrast to other methods, salivary biomarkers are an objective, inexpensive, and noninvasive method to identify individuals with inadequate sleep. Although we have previously shown that inflammatory genes are elevated in saliva samples taken from sleep deprived individuals, it is unclear if inflammatory genes will be elevated in clinical populations with EDS. In this study, salivary samples from individuals with sleep apnea were evaluated using the Taqman low density inflammation array. Transcript levels for 3 genes, including prostaglandin-endoperoxide synthase 2 (PTGS2), were elevated in patients with sleep apnea. Interestingly, PTGS2 was also elevated in patients with EDS but who did not have sleep apnea. These data demonstrate the feasibility of using salivary transcript levels to identify individuals that self-report excessive daytime sleepiness.
UR - http://www.scopus.com/inward/record.url?scp=84927154632&partnerID=8YFLogxK
U2 - 10.1155/2015/539627
DO - 10.1155/2015/539627
M3 - Article
C2 - 25873764
AN - SCOPUS:84927154632
SN - 0962-9351
VL - 2015
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 539627
ER -