Excess congenital non-synonymous variation in leukemia-associated genes in MLL- Infant leukemia: A Children's Oncology Group report

M. C. Valentine, A. M. Linabery, S. Chasnoff, A. E.O. Hughes, C. Mallaney, N. Sanchez, J. Giacalone, N. A. Heerema, J. M. Hilden, L. G. Spector, J. A. Ross, T. E. Druley

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Infant leukemia (IL) is a rare sporadic cancer with a grim prognosis. Although most cases are accompanied by MLL rearrangements and harbor very few somatic mutations, less is known about the genetics of the cases without MLL translocations. We performed the largest exome-sequencing study to date on matched non-cancer DNA from pairs of mothers and IL patients to characterize congenital variation that may contribute to early leukemogenesis. Using the COSMIC database to define acute leukemia-associated candidate genes, we find a significant enrichment of rare, potentially functional congenital variation in IL patients compared with randomly selected genes within the same patients and unaffected pediatric controls. IL acute myeloid leukemia (AML) patients had more overall variation than IL acute lymphocytic leukemia (ALL) patients, but less of that variation was inherited from mothers. Of our candidate genes, we found that MLL3 was a compound heterozygote in every infant who developed AML and 50% of infants who developed ALL. These data suggest a model by which known genetic mechanisms for leukemogenesis could be disrupted without an abundance of somatic mutation or chromosomal rearrangements. This model would be consistent with existing models for the establishment of leukemia clones in utero and the high rate of IL concordance in monozygotic twins.

Original languageEnglish
Pages (from-to)1235-1241
Number of pages7
JournalLeukemia
Volume28
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • MLL3
  • exome
  • infant

Fingerprint Dive into the research topics of 'Excess congenital non-synonymous variation in leukemia-associated genes in MLL- Infant leukemia: A Children's Oncology Group report'. Together they form a unique fingerprint.

Cite this