TY - JOUR
T1 - Examination of the nicotine dependence (NICSNP) consortium findings in the iowa adoption studies population
AU - Philibert, Robert A.
AU - Todorov, Alexandre
AU - Andersen, Allan
AU - Hollenbeck, Nancy
AU - Gunter, Tracy
AU - Heath, Andrew
AU - Madden, Pamela
PY - 2009
Y1 - 2009
N2 - Introduction: Nicotine dependence results from a complex interplay of genetic and environmental factors. Over the past several years, a large number of studies have been performed to identify distinct gene loci containing genetic vulnerability to nicotine dependence. Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches. Methods: We attempted to confirm and extend the most significant findings from the high-density association study and the candidate gene study using the behavioral and genetic resources of the Iowa Adoption Studies, the largest case-control adoption study of substance use in the United States. Results: We found evidence that genetic variation at CHRNA1, CHRNA2, CHRNA7, and CHRNB1 alters susceptibility to nicotine dependence, but we did not replicate any of the most significant single nucleotide polymorphism associations from the NICSNP high-density association study. Discussion: Further examination of the NICSNP findings in other population samples is indicated.
AB - Introduction: Nicotine dependence results from a complex interplay of genetic and environmental factors. Over the past several years, a large number of studies have been performed to identify distinct gene loci containing genetic vulnerability to nicotine dependence. Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches. Methods: We attempted to confirm and extend the most significant findings from the high-density association study and the candidate gene study using the behavioral and genetic resources of the Iowa Adoption Studies, the largest case-control adoption study of substance use in the United States. Results: We found evidence that genetic variation at CHRNA1, CHRNA2, CHRNA7, and CHRNB1 alters susceptibility to nicotine dependence, but we did not replicate any of the most significant single nucleotide polymorphism associations from the NICSNP high-density association study. Discussion: Further examination of the NICSNP findings in other population samples is indicated.
UR - http://www.scopus.com/inward/record.url?scp=64949136433&partnerID=8YFLogxK
U2 - 10.1093/ntr/ntn034
DO - 10.1093/ntr/ntn034
M3 - Article
C2 - 19307444
AN - SCOPUS:64949136433
SN - 1462-2203
VL - 11
SP - 286
EP - 292
JO - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
IS - 3
ER -